Nuclear receptor subfamily 3 group C member 1 (Q2663095)

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mammalian protein found in Homo sapiens
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • nuclear receptor subfamily 3 group C member 1 variant hGR-B(93)
  • nuclear receptor subfamily 3 group C member 1 variant hGR-B(77)
  • nuclear receptor subfamily 3 group C member 1 variant hGR-B(54)
  • NR3C1
  • glucocorticoid receptor
  • glucocorticoid nuclear receptor variant 1
edit
Language Label Description Also known as
English
Nuclear receptor subfamily 3 group C member 1
mammalian protein found in Homo sapiens
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • nuclear receptor subfamily 3 group C member 1 variant hGR-B(93)
  • nuclear receptor subfamily 3 group C member 1 variant hGR-B(77)
  • nuclear receptor subfamily 3 group C member 1 variant hGR-B(54)
  • NR3C1
  • glucocorticoid receptor
  • glucocorticoid nuclear receptor variant 1

Statements

molecular function
protein binding
determination method or standard
IPI
24 references
retrieved
8 April 2019
stated in
Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic identification of glucocorticoid receptor interacting proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid effects
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
retrieved
8 April 2019
stated in
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IPI
cell component
cytoplasm
determination method or standard
IDA
IEA
TAS
5 references
retrieved
8 April 2019
stated in
Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IEA
retrieved
8 April 2019
stated in
A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
retrieved
8 April 2019
stated in
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
retrieved
8 April 2019
stated in
A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
nucleus
determination method or standard
IDA
IEA
TAS
8 references
retrieved
8 April 2019
stated in
Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IEA
retrieved
8 April 2019
stated in
The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
retrieved
8 April 2019
stated in
A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
retrieved
8 April 2019
stated in
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
retrieved
8 April 2019
stated in
A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
GOA
curator
UniProt
UniProt protein ID
P04150
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
retrieved
8 April 2019
stated in
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04150
determination method or standard
IDA
biological process
physically interacts with
Gene Atlas image
PBB GE NR3C1 216321 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

RefSeq protein ID
PDB structure ID
 
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