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Link to original content: https://www.ncbi.nlm.nih.gov/pubmed/33330093
Comparison of Diagnostic Performance of Five Different Ultrasound TI-RADS Classification Guidelines for Thyroid Nodules - PubMed Skip to main page content
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. 2020 Nov 16:10:598225.
doi: 10.3389/fonc.2020.598225. eCollection 2020.

Comparison of Diagnostic Performance of Five Different Ultrasound TI-RADS Classification Guidelines for Thyroid Nodules

Ruoning Yang  1   2 , Xiuhe Zou  3 , Hao Zeng  1 , Yunuo Zhao  1 , Xuelei Ma  1
Affiliations

Comparison of Diagnostic Performance of Five Different Ultrasound TI-RADS Classification Guidelines for Thyroid Nodules

Ruoning Yang et al. Front Oncol. .

Abstract

Objectives: We aimed to evaluate and compare the diagnostic performance of five ultrasound thyroid imaging reporting and data system (TI-RADS) classification guidelines for thyroid nodules through a review and meta-analysis.

Methods: We searched for relevant studies before February 2020 in PubMed. Then we pooled the sensitivity, specificity, likelihood ratios, diagnostic odds ratios, and area under the summary receiver operating characteristic curves. And the diagnostic odds ratios were used to compare the performance.

Results: We totally included 19 studies with 4,696 lesions in this research. The pooled sensitivity of American College of Radiology (ACR) guidelines, American Thyroid Association (ATA) guidelines, TI-RADS proposed by Kwak (Kwak TI-RADS), Korean Thyroid Association/Korean Society of Thyroid Radiology (KTA/KSThR) guidelines for malignancy risk and European Thyroid Association (ETA) guidelines is between 0.84 and 0.94. The pooled specificity is 0.68, 0.44, 0.62, 0.47, and 0.61, respectively. And the RDOR is 1.57 (ACR vs ATA), 1.37 (ACR vs ETA), 1.80 (ACR vs Kawk), 1.74 (ARC vs KTA).

Conclusions: The results suggest that five classification guidelines are all effective methods for differential diagnosis of benign and malignant thyroid nodules and ACR guideline is a better choice.

Keywords: TI-RADS; diagnostic performance; malignancy; meta-analysis; thyroid nodule; ultrasound.

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Figures

Figure 1
Figure 1
Flowchart of the literature search and selection schema.
Figure 2
Figure 2
(A) Risk of bias and applicability concerns graph: review authors’ judgments about each domain presented as percentages across the included studies. (B) Risk of bias and applicability concerns summary: review authors’ judgments about each domain for each included study.
See this image and copyright information in PMC

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