iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://www.ncbi.nlm.nih.gov/pubmed/26581331
Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Nov 18:11:285.
doi: 10.1186/s12917-015-0597-0.

Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture

Veronique Saey  1 , Nele Famaey  2 , Marija Smoljkic  3 , Erik Claeys  4 , Gunther van Loon  5 , Richard Ducatelle  6 , Margreet Ploeg  7 , Catherine Delesalle  8   9 , Andrea Gröne  10 , Luc Duchateau  11 , Koen Chiers  12
Affiliations

Biomechanical and biochemical properties of the thoracic aorta in warmblood horses, Friesian horses, and Friesians with aortic rupture

Veronique Saey et al. BMC Vet Res. .

Abstract

Background: Thoracic aortic rupture and aortopulmonary fistulation are rare conditions in horses. It mainly affects Friesian horses. Intrinsic differences in biomechanical properties of the aortic wall might predispose this breed. The biomechanical and biochemical properties of the thoracic aorta were characterized in warmblood horses, unaffected Friesian horses and Friesians with aortic rupture in an attempt to unravel the underlying pathogenesis of aortic rupture in Friesian horses. Samples of the thoracic aorta at the ligamentum arteriosum (LA), mid thoracic aorta (T1) and distal thoracic aorta (T2) were obtained from Friesian horses with aortic rupture (A), nonaffected Friesian (NA) and warmblood horses (WB). The biomechanical properties of these samples were determined using uniaxial tensile and rupture assays. The percentages of collagen and elastin (mg/mg dry weight) were quantified.

Results: Data revealed no significant biomechanical nor biochemical differences among the different groups of horses. The distal thoracic aorta displayed an increased stiffness associated with a higher collagen percentage in this area and a higher load-bearing capacity compared to the more proximal segments.

Conclusions: Our findings match reported findings in other animal species. Study results did not provide evidence that the predisposition of the Friesian horse breed for aortic rupture can be attributed to altered biomechanical properties of the aortic wall.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Sample stress strain curve. E10, E20 and E30 are the tangent stiffness moduli. The maximum engineering stress at failure is presented as σfail, σb and σe are the tensile stresses at the beginning and end of the relaxation phase
Fig. 2
Fig. 2
Maximum engineering stress at failure of the equine thoracic aorta at 3 sample locations (LA-T1-T2) in 3 groups of horses (red: Friesian horses with aortic rupture; green: nonaffected Friesian horses; blue: nonaffected warmblood horses) (*: p < 0.001)
Fig. 3
Fig. 3
Relaxation time, determined during cyclic testing, of the equine thoracic aorta at 3 sample locations (LA-T1-T2) in 3 groups of horses (red: Friesian horses with aortic rupture; green: nonaffected Friesian horses; blue: nonaffected warmblood horses) (*: p < 0.002)
Fig. 4
Fig. 4
Collagen percentage of the equine thoracic aorta at 3 sample locations (LA-T1-T2) in 3 groups of horses (red: Friesian horses with aortic rupture; green: nonaffected Friesian horses; blue: nonaffected warmblood horses) (*: p < 0.001)
Fig. 5
Fig. 5
Elastin percentage of the equine thoracic aorta at 3 sample locations (LA-T1-T2) in 3 groups of horses (red: Friesian horses with aortic rupture; green: nonaffected Friesian horses; blue: nonaffected warmblood horses)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Holzapfel GA, Gasser TC, Ogden RW. A new constitutive framework for arterial wall mechanics and a comparative study of material models. J Elasticity. 2000;61:1–48. doi: 10.1023/A:1010835316564. - DOI
    1. Wolinsky H, Glagov S. A lamellar unit of aortic medial structure and function in mammals. Circ Res. 1967;20:99–111. doi: 10.1161/01.RES.20.1.99. - DOI - PubMed
    1. Avanzini A, Battini D, Bagozzi L, Bisleri G. Biomechanical evaluation of ascending aortic aneurysms. BioMed Res Int. 2014 - PMC - PubMed
    1. Grange JJ, Davis V, Baxter BT. Pathogenesis of abdominal aortic aneurysm: an update and look toward the future. Cardiovasc Surg. 1997;5:256–65. doi: 10.1016/S0967-2109(97)00018-5. - DOI - PubMed
    1. Rooney JR, Prickett ME, Crowe MW. Aortic ring rupture in stallions. Pathol Vet. 1967;4:268–74. - PubMed

LinkOut - more resources