iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://www.ncbi.nlm.nih.gov/pubmed/19688100
A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009:5:593-605.
doi: 10.2147/vhrm.s6203. Epub 2009 Aug 6.

A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention

Ji-Guang Wang  1
Affiliations
Review

A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention

Ji-Guang Wang. Vasc Health Risk Manag. 2009.

Abstract

Stroke is a leading cause of death and disability worldwide. The importance of lowering blood pressure for reducing the risk of stroke is well established. However, not all the benefits of antihypertensive treatments in stroke can be accounted for by reductions in BP and there may be differences between antihypertensive classes as to which provides optimal protection. Dihydropyridine calcium channel blockers, such as amlodipine, and angiotensin receptor blockers, such as valsartan, represent the two antihypertensive drug classes with the strongest supportive data for the prevention of stroke. Therefore, when combination therapy is required, a combination of these two antihypertensive classes represents a logical approach.

Keywords: angiotensin; blood pressure; calcium channel; cerebrovascular; hypertension; stroke.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Relationship between SBP and stroke. Reprinted from The Lancet, 362, Turnbull F; Blood Pressure Lowering Treatment Trialists’ Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials, 1527–1535. Copyright © 2003, with permission from elsevier. Notes: A, CCB vs placebo; B, ACei vs placebo; C, more intensive vs less intensive BP-lowering; D, ARB vs control; e, ACei vs CCB; F, CCB vs diuretic or β-blocker; G, ACei vs diuretic and β-blocker. Abbreviations: ACei, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BP, blood pressure; CCB, calcium channel blocker; SBP, systolic blood pressure.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Meairs S, Wahlgren N, Dirnagl U, Lindvall O, Rothwell P, Baron JC, et al. Stroke research priorities for the next decade – a representative view of the European scientific community. Cerebrovasc Dis. 2006;22:2–3. 75–82. - PubMed
    1. WHO atlas of heart disease and stroke. [Accessed July 8, 2009]. http://www.who.int/cardiovascular_diseases/en/cvd_atlas_15_burden_stroke....
    1. Truelsen T, Piechowski-JóŸwiak B, Bonita R, Mathers C, Bogousslavsky J, Boysen G. Stroke incidence and prevalence in Europe: a review of available data. Eur J Neurol. 2006;13(6):581–598. - PubMed
    1. Paul SL, Srikanth VK, Thrift AG. The large and growing burden of stroke. Curr Drug Targets. 2007;8(7):786–793. - PubMed
    1. Goldstein LB, Adams R, Alberts MJ, Appel LJ, Brass LM, Bushnell CD, et al. American Heart Association; American Stroke Association Stroke Council. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2006;113(24):e873–e923. - PubMed

Publication types

MeSH terms

Substances