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Link to original content: https://www.ncbi.nlm.nih.gov/pubmed/1475172
Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport - PubMed Skip to main page content
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Review
. 1992 Dec 11;14(6):338-48.
doi: 10.1007/BF01970169.

Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport

J B Van Bree  1 , A G De Boer, M Danhof, D D Breimer
Affiliations
Review

Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport

J B Van Bree et al. Pharm Weekbl Sci. .

Abstract

This is part II of a review on the transport of drugs across the blood-brain barrier. In this part, the emphasis is on the various experimental techniques that can be used to characterize the blood-brain barrier transport of drugs. Generally speaking, three approaches can be distinguished: in vitro techniques using isolated brain capillaries, cerebrovascular endothelial cells in primary culture or endothelium-derived cell lines; in vivo techniques (both single-passage and multi-passage techniques) and in situ perfusion techniques. Each of these techniques has specific advantages and disadvantages associated with it. Therefore, in many instances, a combination of different approaches is needed to study the fundamental aspects of drug transport across the blood-brain barrier.

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References

    1. Brain Res. 1980 Jun 16;192(1):17-28 - PubMed
    1. J Neurochem. 1980 Aug;35(2):374-81 - PubMed
    1. J Neurochem. 1992 Feb;58(2):667-72 - PubMed
    1. J Pharmacol Exp Ther. 1960 Sep;130:20-5 - PubMed
    1. J Anat. 1979 Sep;129(Pt 2):261-72 - PubMed

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