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Link to original content: https://www.ncbi.nlm.nih.gov/gene/6361
CCL17 C-C motif chemokine ligand 17 [Homo sapiens (human)] - Gene - NCBI
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CCL17 C-C motif chemokine ligand 17 [ Homo sapiens (human) ]

Gene ID: 6361, updated on 27-Nov-2024

Summary

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Official Symbol
CCL17provided by HGNC
Official Full Name
C-C motif chemokine ligand 17provided by HGNC
Primary source
HGNC:HGNC:10615
See related
Ensembl:ENSG00000102970 MIM:601520; AllianceGenome:HGNC:10615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARC; ABCD-2; SCYA17; A-152E5.3
Summary
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
Expression
Biased expression in appendix (RPKM 2.1), lymph node (RPKM 1.4) and 13 other tissues See more
Orthologs
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Genomic context

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See CCL17 in Genome Data Viewer
Location:
16q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57396093..57416063)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63191214..63211239)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57438679..57449975)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:57396657-57396838 Neighboring gene C-C motif chemokine ligand 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57412503-57413083 Neighboring gene C-X3-C motif chemokine ligand 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57417624-57418314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57418315-57419004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450029-57450544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57450545-57451060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57451577-57452091 Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene Sharpr-MPRA regulatory region 5957 Neighboring gene coenzyme Q9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Serum TARC levels are strongly correlated with blood eosinophil count in patients with drug eruptions. Komatsu-Fujii T, et al. Allergol Int, 2017 Jan. PMID 27497618
  2. Serum thymus and activation-regulated chemokine level monitoring may predict disease relapse detected by PET scan after reduced-intensity allogeneic stem cell transplantation in patients with Hodgkin lymphoma. Farina L, et al. Biol Blood Marrow Transplant, 2014 Dec. PMID 25240818
  3. Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments. Yasukochi Y, et al. Asian Pac J Allergy Immunol, 2014 Sep. PMID 25268342
  4. Serum chemokine CCL17/thymus activation and regulated chemokine is correlated with coronary artery diseases. Ye Y, et al. Atherosclerosis, 2015 Feb. PMID 25555269
  5. [Association of single nucleotide polymorphisms in TARC/CCL17 gene with Kawasaki disease and its clinical characteristics]. Liu F, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2015 Jul. PMID 26182268

See all (173) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment.
    Title: Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment.
  2. Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.
    Title: Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.
  3. CCL17/TARC in autoimmunity and inflammation-not just a T-cell chemokine.
    Title: CCL17/TARC in autoimmunity and inflammation-not just a T-cell chemokine.
  4. Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study.
    Title: Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study.
  5. Serum thymus and activation-regulated chemokine is a surrogate marker for bullous pemphigoid disease activity.
    Title: Serum thymus and activation-regulated chemokine is a surrogate marker for bullous pemphigoid disease activity.
  6. CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction.
    Title: CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction.
  7. Serum chemokine CC-motif ligand 17 is a predictive marker of severe COVID-19 in haemodialysis patients: A retrospective observational study.
    Title: Serum chemokine CC-motif ligand 17 is a predictive marker of severe COVID-19 in haemodialysis patients: A retrospective observational study.
  8. IFN-lambda3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.
    Title: IFN-λ3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.
  9. Spatial Transcriptomics Analysis Reveals that CCL17 and CCL22 are Robust Indicators of a Suppressive Immune Environment in Angioimmunoblastic T Cell Lymphoma (AITL).
    Title: Spatial Transcriptomics Analysis Reveals that CCL17 and CCL22 are Robust Indicators of a Suppressive Immune Environment in Angioimmunoblastic T Cell Lymphoma (AITL).
  10. Serum thymus and activation-regulated chemokine (TARC) levels correlate with atopic dermatitis disease severity in patients < 6 months.
    Title: Serum thymus and activation-regulated chemokine (TARC) levels correlate with atopic dermatitis disease severity in patients < 6 months.
Submit: New GeneRIF Correction See all GeneRIFs (148)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138271, MGC138273

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in chemotaxis TAS
Traceable Author Statement
more info
  
involved_in killing of cells of another organism IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C-C motif chemokine 17
Names
CC chemokine TARC
T cell-directed CC chemokine
chemokine (C-C motif) ligand 17
small inducible cytokine subfamily A (Cys-Cys), member 17
small-inducible cytokine A17
thymus and activation-regulated chemokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002987.3 → NP_002978.1  C-C motif chemokine 17 precursor

    See identical proteins and their annotated locations for NP_002978.1

    Status: REVIEWED

    Source sequence(s)
    AC009052, BC069107
    Consensus CDS
    CCDS10780.1
    UniProtKB/Swiss-Prot
    A0N0Q9, Q2M287, Q92583
    Related
    ENSP00000219244.4, ENST00000219244.9
    Conserved Domains (1) summary
    cd00272
    Location:33 → 89
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57396093..57416063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023530.2 → XP_016879019.1  C-C motif chemokine 17 isoform X1

    Conserved Domains (1) summary
    cd00272
    Location:62 → 118
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

  2. XM_011523256.3 → XP_011521558.1  C-C motif chemokine 17 isoform X2

    See identical proteins and their annotated locations for XP_011521558.1

    Conserved Domains (1) summary
    cd00272
    Location:61 → 117
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

  3. XM_047434448.1 → XP_047290404.1  C-C motif chemokine 17 isoform X3

    UniProtKB/Swiss-Prot
    A0N0Q9, Q2M287, Q92583
    Related
    ENSP00000480147.1, ENST00000616880.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63191214..63211239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313597.1 → XP_054169572.1  C-C motif chemokine 17 isoform X1

  2. XM_054313598.1 → XP_054169573.1  C-C motif chemokine 17 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92583.1 GenPept UniProtKB/Swiss-Prot:Q92583

Gene LinkOut

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