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Regulated nucleosome mobility and the histone code | Nature Structural & Molecular Biology
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Regulated nucleosome mobility and the histone code

Nature Structural & Molecular Biology volume 11, pages 1037–1043 (2004)Cite this article

Abstract

Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.

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Figure 1: Annotated map of previously known and newly identified histone modifications on the surface of the X. laevis nucleosome core particle26.
Figure 2: The regulated nucleosome mobility model.
Figure 3: Regulated nucleosome mobility, a missing link in the regulation of chromatin dynamics.

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Acknowledgements

This work is supported in part by the Ruth L. Kirschstein National Research Service Award postdoctoral fellowship to M.S.C. from the US National Cancer Institute, and by a grant from the US National Institutes of Health to J.D.B. and C.W.

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Authors and Affiliations

  1. Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, 21205, Maryland, USA

    Michael S Cosgrove & Cynthia Wolberger

  2. Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, 21205, Maryland, USA

    Jef D Boeke

  3. High Throughput Biology Center, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, 21205, Maryland, USA

    Jef D Boeke

  4. Howard Hughes Medical Institute, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, 21205, Maryland, USA

    Cynthia Wolberger

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  1. Michael S Cosgrove
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Correspondence to Jef D Boeke.

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Cosgrove, M., Boeke, J. & Wolberger, C. Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol 11, 1037–1043 (2004). https://doi.org/10.1038/nsmb851

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