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Link to original content: https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7551
lofepramine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY

lofepramine   Click here for help

GtoPdb Ligand ID: 7551

Synonyms: Gamanil ® | Lomont ® | WHR-2908A
Approved drug
lofepramine is an approved drug
Compound class: Synthetic organic
Comment: Marketed formulations may contain lofepramine hydrochloride (PubChem CID 33611).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: lofepramine

lofepramine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 23.55
Molecular weight 418.18
XLogP 6.01
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN(CC(=O)c1ccc(cc1)Cl)CCCN1c2ccccc2CCc2c1cccc2
Isomeric SMILES CN(CC(=O)c1ccc(cc1)Cl)CCCN1c2ccccc2CCc2c1cccc2
InChI InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
InChI Key SAPNXPWPAUFAJU-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
Withdrawn drug? Yes
IUPAC Name Click here for help
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
International Nonproprietary Names Click here for help
INN number INN
2909 lofepramine
Synonyms Click here for help
Gamanil ® | Lomont ® | WHR-2908A
Database Links Click here for help
CAS Registry No. 23047-25-8
ChEBI CHEBI:47782
ChEMBL Ligand CHEMBL87708
DrugCentral Ligand 1592
GtoPdb PubChem SID 223365887
PubChem CID 3947
Search Google for chemical match using the InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SAPNXPWPAUFAJU
Search PubMed clinical trials lofepramine
Search PubMed titles lofepramine
Search PubMed titles/abstracts lofepramine
UniChem Compound Search for chemical match using the InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N
Wikipedia Lofepramine

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Tocris
Lofepramine (links to external site)
Cat. No. 2545