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Corticosteroids, interleukin-6 inhibitors receptor antagonists, and janus kinase inhibitors probably reduce mortality and confer other important benefits in patients with severe covid-19. Molnupiravir probably reduces admission to hospital in patients with non-severe covid-19.
Much of the evidence remains very low certainty and we therefore anticipate future studies evaluating drugs for prophylaxis may change the results for SARS-CoV-2 infection, admission to hospital and mortality outcomes. Both hydroxychloroquine and vitamin C combined with zinc probably increase adverse effects.
There is no clear effect of bamlanivimab, convalescent plasma, or IVIG on patient- important outcomes. Properly evaluating the safety and efficacy of humoral and cellular therapies for the treatment of covid-19 will requires data from additional large randomised trials.
A tool that facilitates assessment of the certainty of the evidence with the GRADE approach for NMA. The spreadsheet incorporates automation of several of the steps required to complete the assessment.
Download GRADE Assessment SpreadsheetThis website provides up-to-date information about the use of pharmaceuticals, antiviral antibodies, and blood products in treatment and prevention of COVID-19. The evidence presented is the joint effort of an international group of researchers. The core group is based at McMaster University, and collaborates closely with the Magic Evidence Ecosystem Foundation and The BMJ. We also work independently of, but in collaboration with, The World Health Organization. This work is partially funded by the Canadian Institutes of Health Research operating grants VR4-172738 and MM1-174897.
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