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Link to original content: https://pubmed.ncbi.nlm.nih.gov/9327671/
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Clinical Trial
. 1997 Oct;21(8):811-4; discussion 814-5.
doi: 10.1007/s002689900311.

Antibiotic prophylaxis and open groin hernia repair

E W Taylor  1 , D J Byrne, D J Leaper, S J Karran, M K Browne, K J Mitchell
Affiliations
Clinical Trial

Antibiotic prophylaxis and open groin hernia repair

E W Taylor et al. World J Surg. 1997 Oct.

Abstract

Antibiotic prophylaxis is not routinely given for nonimplant, clean operations, although this view has recently been challenged. We have conducted a randomized multicenter, double-blind prospective trial to compare co-amoxiclav with placebo in 619 patients undergoing open groin hernia repair. Altogether 563 (91%) patients fulfilled the protocol; 283 received co-amoxiclav and 280 placebo. There was no difference between the groups in the number of patients receiving local or general anesthetic, the type of repair performed, the use of a subcutaneous fat suture, the type of skin closure used, the use of wound analgesia, or the use of a wound drain. Patients were given a card to return to the hospital in the event of their wound discharging or their needing to see their general practitioner. All patients were reviewed at approximately 6 weeks after operation. Fifty (8.9%) patients sustained a wound infection, 25 in the co-amoxiclav group and 25 in the placebo group. We conclude that antibiotic prophylaxis is of no benefit to patients undergoing open groin hernia repair.

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