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Link to original content: https://pubmed.ncbi.nlm.nih.gov/9306402/
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo - PubMed Skip to main page content
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. 1997 Sep;15(9):871-5.
doi: 10.1038/nbt0997-871.

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

R Zufferey  1 , D Nagy, R J Mandel, L Naldini, D Trono
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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

R Zufferey et al. Nat Biotechnol. 1997 Sep.

Abstract

Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted. This multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vivo into adult neurons. These data demonstrate the potential of lentiviral vectors in human gene therapy.

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