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Link to original content: https://pubmed.ncbi.nlm.nih.gov/8906799
Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin - PubMed Skip to main page content
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. 1996 Nov 15;157(10):4277-81.

Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin

T Okura  1 , L Gong, T Kamitani, T Wada, I Okura, C F Wei, H M Chang, E T Yeh
Affiliations
  • PMID: 8906799

Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin

T Okura et al. J Immunol. .

Abstract

Fas/APO-1 and TNF receptor 1 share a common signaling motif in their cytoplasmic tail called the "death domain." Using the death domain as bait in the yeast two-hybrid system, several death domain-containing proteins that participate in cell death signaling have been identified. Here we report the isolation of a novel protein, sentrin, which interacts with Fas/APO-1 and TNF receptor 1 but not with FADD/MORT1 or CD40. Two-hybrid interaction assays reveal that sentrin associates only with the signal-competent forms of Fas/APO-1 or TNF receptor 1 death domains. Sentrin is a novel protein of 101 amino acids with homology to ubiquitin, Nedd8, and a Saccharomyces cerevisiae protein, Smt3. When overexpressed, sentrin provides protection against both anti-Fas/APO-1 and TNF-induced cell death.

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