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Link to original content: https://pubmed.ncbi.nlm.nih.gov/8797240/
Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication - PubMed Skip to main page content
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Comparative Study
. 1996 May 31;67(1):29-38.
doi: 10.1016/0925-4927(96)02817-x.

Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication

N D Volkow  1 , H Gillespie, N Mullani, L Tancredi, C Grant, A Valentine, L Hollister
Affiliations
Comparative Study

Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication

N D Volkow et al. Psychiatry Res. .

Abstract

Despite the widespread abuse of marijuana, knowledge about its effects in the human brain is limited. Brain glucose metabolism with and without delta 9 tetrahydrocannabinol (THC) (main psychoactive component of marijuana) was evaluated in eight normal subjects and eight chronic marijuana abusers with positron emission tomography. At baseline, marijuana abusers showed lower relative cerebellar metabolism than normal subjects. THC increased relative cerebellar metabolism in all subjects, but only abusers showed increases in orbitofrontal cortex, prefrontal cortex, and basal ganglia. Cerebellar metabolism during THC intoxication was significantly correlated with the subjective sense of intoxication. The decreased cerebellar metabolism in marijuana abusers at baseline could account for the motor deficits previously reported in these subjects. The activation of orbitofrontal cortex and basal ganglia by THC in the abusers but not in the normal subjects could underlie one of the mechanisms leading to the drive and the compulsion to self-administer the drug observed in addicted individuals.

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