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Link to original content: https://pubmed.ncbi.nlm.nih.gov/8778243/
Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase - PubMed Skip to main page content
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. 1996 May;59(5):525-7.
doi: 10.1021/np960149h.

Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

H D Sun  1 , S X Qiu, L Z Lin, Z Y Wang, Z W Lin, T Pengsuparp, J M Pezzuto, H H Fong, G A Cordell, N R Farnsworth
Affiliations

Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

H D Sun et al. J Nat Prod. 1996 May.

Abstract

An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.

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