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Link to original content: https://pubmed.ncbi.nlm.nih.gov/8319905/
The p53-mdm-2 autoregulatory feedback loop - PubMed Skip to main page content
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. 1993 Jul;7(7A):1126-32.
doi: 10.1101/gad.7.7a.1126.

The p53-mdm-2 autoregulatory feedback loop

X Wu  1 , J H Bayle, D Olson, A J Levine
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Free article

The p53-mdm-2 autoregulatory feedback loop

X Wu et al. Genes Dev. 1993 Jul.
Free article

Abstract

The p53 protein can bind to a set of specific DNA sequences, and this may activate the transcription of genes adjacent to these DNA elements. The mdm-2 gene is shown here to contain a p53 DNA-binding site and a genetically responsive element such that expression of the mdm-2 gene can be regulated by the level of wild-type p53 protein. The mdm-2 protein, in turn, can complex with p53 and decrease its ability to act as a positive transcription factor at the mdm-2 gene-responsive element. In this way, the mdm-2 gene is autoregulated. The p53 protein regulates the mdm-2 gene at the level of transcription, and the mdm-2 protein regulates the p53 protein at the level of its activity. This creates a feedback loop that regulates both the activity of the p53 protein and the expression of the mdm-2 gene.

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