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Link to original content: https://pubmed.ncbi.nlm.nih.gov/8202160/
cMpl ligand is a humoral regulator of megakaryocytopoiesis - PubMed Skip to main page content
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. 1994 Jun 16;369(6481):571-4.
doi: 10.1038/369571a0.

cMpl ligand is a humoral regulator of megakaryocytopoiesis

F Wendling  1 , E Maraskovsky, N Debili, C Florindo, M Teepe, M Titeux, N Methia, J Breton-Gorius, D Cosman, W Vainchenker
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cMpl ligand is a humoral regulator of megakaryocytopoiesis

F Wendling et al. Nature. .

Abstract

Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors, and the second, thrombopoietin, is a megakaryocyte maturation factor. Neither of these factors has been fully characterized. The proto-oncogene c-mpl, an orphan member of the haematopoietin receptor family, is specifically involved in megakaryocyte regulation. Here we present evidence that the c-mpl-encoded receptor binds a ligand (c-Mpl ligand) which is a humoral factor implicated in platelet homeostasis. Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule.

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Comment in

  • Blood. Thrombopoietin--at last.
    Metcalf D. Metcalf D. Nature. 1994 Jun 16;369(6481):519-20. doi: 10.1038/369519a0. Nature. 1994. PMID: 8202150 No abstract available.

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