Polyglycolic acid, silk, and topical ampicillin. Their use in hernia repair and cholecystectomy
- PMID: 6243916
- DOI: 10.1001/archsurg.1980.01380030041009
Polyglycolic acid, silk, and topical ampicillin. Their use in hernia repair and cholecystectomy
Abstract
The effect of topical ampicillin sodium and polyglycolic acid and silk sutures on the recurrence of an existing hernia or an incisional hernia and on infection rates in clean abdominal wounds (herniotomies and simple cholecystectomies) was studied in a triple-blind, randomized trial with 398 consecutive patients. One infection, three suture sinuses, and two incisional hernias occurred among 113 patients with cholecystectomies, while the corresponding rates in 285 patients with hernia repairs were 11 infections, no suture sinuses, and three recurrent hernias. No effect of ampicillin could be demonstrated, nor was any difference between polyglycolic acid and silk sutures shown. No interaction between the antibiotic and suture material was found, and no side effects were observed. Wound infection was significantly more frequent in patients with postoperative seromas or hematomas.
Similar articles
-
Absorbable suture in hernia repair.Acta Chir Scand. 1984;150(1):41-3. Acta Chir Scand. 1984. PMID: 6322489 Clinical Trial.
-
Polyglycolic acid (Dexon) versus Mersilene in repair of inguinal hernia.Acta Chir Scand. 1984;150(5):385-7. Acta Chir Scand. 1984. PMID: 6091382 Clinical Trial.
-
[Polyglyconate or polyglycolic acid suture in patients with suspected impaired wound healing].Ugeskr Laeger. 1997 Feb 17;159(8):1100-3. Ugeskr Laeger. 1997. PMID: 9072856 Clinical Trial. Danish.
-
Prevention of incisional hernias: how to close a midline incision.Surg Clin North Am. 2013 Oct;93(5):1027-40. doi: 10.1016/j.suc.2013.06.009. Surg Clin North Am. 2013. PMID: 24035074 Review.
-
[Current standards of abdominal wall closure techniques : Conventional suture techniques].Chirurg. 2016 Sep;87(9):737-743. doi: 10.1007/s00104-016-0231-0. Chirurg. 2016. PMID: 27392763 Review. German.
Cited by
-
Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair.Cochrane Database Syst Rev. 2020 Apr 21;4(4):CD003769. doi: 10.1002/14651858.CD003769.pub5. Cochrane Database Syst Rev. 2020. PMID: 32315460 Free PMC article.
-
The role of saline irrigation prior to wound closure in the reduction of surgical site infection: protocol for a systematic review and meta-analysis.Syst Rev. 2018 Oct 5;7(1):152. doi: 10.1186/s13643-018-0813-7. Syst Rev. 2018. PMID: 30286812 Free PMC article.
-
Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery.Br J Surg. 2017 Jan;104(2):e106-e117. doi: 10.1002/bjs.10441. Br J Surg. 2017. PMID: 28121028 Free PMC article. Review.
-
Does topical rifampicin reduce the risk of surgical field infection in hernia repair?Ulus Cerrahi Derg. 2013 Jun 1;29(2):54-8. doi: 10.5152/UCD.2013.35. eCollection 2013. Ulus Cerrahi Derg. 2013. PMID: 25931846 Free PMC article.
-
Hernia, mesh, and topical antibiotics, especially gentamycin: seeking the evidence for the perfect outcome….Front Surg. 2015 Feb 4;1:53. doi: 10.3389/fsurg.2014.00053. eCollection 2014. Front Surg. 2015. PMID: 25699259 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
