iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://pubmed.ncbi.nlm.nih.gov/36009817
Effect of Ghrelin on the Cardiovascular System - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug 8;11(8):1190.
doi: 10.3390/biology11081190.

Effect of Ghrelin on the Cardiovascular System

Hiroshi Hosoda  1   2
Affiliations
Review

Effect of Ghrelin on the Cardiovascular System

Hiroshi Hosoda. Biology (Basel). .

Abstract

Ghrelin, an n-octanoyl-modified 28-amino-acid-peptide, was first discovered in the human and rat stomach as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Ghrelin-GHS-R1a signaling regulates feeding behavior and energy balance, promotes vascular activity and angiogenesis, improves arrhythmia and heart failure, and also protects against cardiovascular disease by suppressing cardiac remodeling after myocardial infarction. Ghrelin's cardiovascular protective effects are mediated by the suppression of sympathetic activity; activation of parasympathetic activity; alleviation of vascular endothelial dysfunction; and regulation of inflammation, apoptosis, and autophagy. The physiological functions of ghrelin should be clarified to determine its pharmacological potential as a cardiovascular medication.

Keywords: GHS-R; cardiovascular system; des-acyl ghrelin; ghrelin; growth hormone; sympathetic activity.

PubMed Disclaimer

Conflict of interest statement

H.H. received financial support from Tosoh Bioscience.

Figures

Figure 1
Figure 1
Effect of ghrelin-GHS-R1a pathway on the cardiovascular system. Ghrelin affects the cardiovascular system in many different ways, including inhibiting sympathetic activity, activating parasympathetic activity, improving energy balance, and facilitating mechanisms mediated by GH and IGF-1, thereby improving cardiac function in heart failure. Some of the effects may include direct actions on the cardiovascular system. CVS, cardiovascular system.
Figure 2
Figure 2
Structure and biological significance of human ghrelin.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–660. doi: 10.1038/45230. - DOI - PubMed
    1. Hosoda H., Kojima M., Mizushima T., Shimizu S., Kangawa K. Structural divergence of human ghrelin: Identification of multiple ghrelin-derived molecules produced by post-translational processing. J. Biol. Chem. 2003;278:64–70. doi: 10.1074/jbc.M205366200. - DOI - PubMed
    1. Yang J., Brown M.S., Liang G., Grishin N.V., Goldstein J.L. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008;132:387–396. doi: 10.1016/j.cell.2008.01.017. - DOI - PubMed
    1. Kaiya H., Miyazato M., Kangawa K., Peter R.E., Unniappan S. Ghrelin: A multifunctional hormone in non-mammalian vertebrates. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2008;149:109–128. doi: 10.1016/j.cbpa.2007.12.004. - DOI - PubMed
    1. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., Matsukura S., Kangawa K., Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology. 2000;141:4255–4261. doi: 10.1210/endo.141.11.7757. - DOI - PubMed

Grants and funding

This research was supported by AMED under Grant Number JP22ck0106726.

LinkOut - more resources