iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://pubmed.ncbi.nlm.nih.gov/3312096
Requirements and selection of an animal model - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1987 Jun;23(6):551-5.

Requirements and selection of an animal model

M K Davidson  1 , J R Lindsey, J K Davis
Affiliations
  • PMID: 3312096
Review

Requirements and selection of an animal model

M K Davidson et al. Isr J Med Sci. 1987 Jun.

Abstract

There are two broad classes of models: those based on analogy (similar structures imply similar functions), and those based on homology (structures derived from the same evolutionary precursor have the same or similar functions). There are four main categories of animal models: 1) induced or experimental models, that attempt to reproduce conditions found in the original species, 2) spontaneous or natural models, that are recognized as being similar to some condition in the original species, 3) negative or nonreactive models, that are the normal counterparts of a disease model, and 4) orphan models, that are animal diseases for which no human or animal counterpart is known. The selection of any model, but particularly animal models, for research should be based on the following considerations: 1) appropriateness as an analog, 2) transferability of information, 3) genetic uniformity of organisms, where applicable, 4) background knowledge of biological properties, 5) cost and availability, 6) generalizability of the results, 7) ease of and adaptability to experimental manipulation, 8) ecological consequences, and 9) ethical implications. The criteria for selection or rejection of particular animal models also include customary practice within a particular discipline, the existence of diseases or conditions that might complicate results, the existing body of knowledge on the problem under consideration, and special features of the animal, such as unique responses or microflora, that may make a particular species useful.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types