Characteristics of SARS-CoV-2 and COVID-19
- PMID: 33024307
- PMCID: PMC7537588
- DOI: 10.1038/s41579-020-00459-7
Characteristics of SARS-CoV-2 and COVID-19
Erratum in
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Author Correction: Characteristics of SARS-CoV-2 and COVID-19.Nat Rev Microbiol. 2022 May;20(5):315. doi: 10.1038/s41579-022-00711-2. Nat Rev Microbiol. 2022. PMID: 35197601 Free PMC article. No abstract available.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named 'coronavirus disease 2019' (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail.
Conflict of interest statement
The authors declare no competing interests.
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