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Link to original content: https://pubmed.ncbi.nlm.nih.gov/32887894
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. 2020 Sep 4;10(1):14640.
doi: 10.1038/s41598-020-71495-9.

Low levels of salivary metals, oral microbiome composition and dental decay

Elyse Davis  1   2 , Kelly M Bakulski  2 , Jaclyn M Goodrich  3 , Karen E Peterson  3   4 , Mary L Marazita  5   6   7 , Betsy Foxman  8   9
Affiliations

Low levels of salivary metals, oral microbiome composition and dental decay

Elyse Davis et al. Sci Rep. .

Abstract

Salivary microbiome composition can change following exposure to environmental toxicants, e.g., heavy metals. We hypothesized that levels of salivary nutrients and metals would correlate with salivary microbiome composition and be associated with dental decay. Here we assess the salivary concentrations of 5 essential minerals (cobalt, copper, manganese, molybdenum, and zinc), 4 metals with some evidence of normal physiological function (chromium, nickel, tungsten, and vanadium), and 12 with known toxicity (antimony, arsenic, barium, beryllium, cadmium, cesium, lead, mercury, platinum, thallium, tin, and uranium), and their associations with salivary microbiome composition and dental decay in 61 children and adults. 16 metals were detected in 54% of participants; 8 were found in all. Marked differences in salivary bacterial taxa were associated with levels of antimony, arsenic, and mercury, after adjusting for multiple testing. Further, antimony levels were associated with the presence of decayed teeth. Thus, salivary metal levels, even at low concentrations, may impact oral health.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Adjusted odds ratios for presence of decayed teeth by selected heavy metal tertile (high versus low (circles), medium versus low (triangles). X axis is shown on a log scale. Saliva samples were collected from 61 individuals from the Center for Oral Health Research in Appalachia Study.
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