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Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair - PubMed Skip to main page content
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Meta-Analysis
. 2020 Apr 21;4(4):CD003769.
doi: 10.1002/14651858.CD003769.pub5.

Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair

Claudia C Orelio  1 , Coen van Hessen  2 , Francisco Javier Sanchez-Manuel  3 , Theodorus J Aufenacker  4 , Rob Jpm Scholten  5
Affiliations
Meta-Analysis

Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair

Claudia C Orelio et al. Cochrane Database Syst Rev. .

Abstract

Background: Inguinal or femoral hernia is a tissue protrusion in the groin region and has a cumulative incidence of 27% in adult men and of 3% in adult women. As most hernias become symptomatic over time, groin hernia repair is one of the most frequently performed surgical procedures worldwide. This type of surgery is considered 'clean' surgery with wound infection rates expected to be lower than 5%. For clean surgical procedures, antibiotic prophylaxis is not generally recommended. However after the introduction of mesh-based hernia repair and the publication of studies that have high wound infection rates the debate as to whether antibiotic prophylaxis is required to prevent postoperative wound infections started again.

Objectives: To determine the effectiveness of antibiotic prophylaxis in reducing postoperative (superficial and deep) wound infections in elective open inguinal and femoral hernia repair.

Search methods: We searched several electronic databases: Cochrane Registry of Studies Online, MEDLINE Ovid, Embase Ovid, Scopus and Science Citation Index (search performed on 12 November 2019). We also searched two trial registers and the reference list of included studies.

Selection criteria: We included randomised controlled trials comparing any type of antibiotic prophylaxis versus placebo or no treatment for preventing postoperative wound infections in adults undergoing inguinal or femoral open hernia repair surgery (tissue repair and mesh repair).

Data collection and analysis: Two review authors independently selected studies, extracted data and assessed risk of bias. We separately analysed results for two different surgical methods (herniorrhaphy and hernioplasty). Several studies revealed infection rates that were higher than the expected 5% for clean surgery and we therefore divided studies into two subgroups: high infection risk environments (≥ 5% infection rate); and low infection risk environments (< 5% infection rate). We performed meta-analyses with random-effects models. We analysed three outcomes: superficial surgical site infections (SSSI); deep surgical site infections (DSSI); and all postoperative wound infections (SSSI + DSSI).

Main results: In this review update we identified and included 10 new studies. In total, we included 27 studies with 8308 participants in this review. It is uncertain whether antibiotic prophylaxis as compared to placebo (or no treatment) prevents all types of postoperative wound infections after herniorrhaphy surgery (risk ratio (RR) 0.86, 95% confidence interval (CI) 0.56 to 1.33; 5 studies, 1865 participants; very low quality evidence). Subgroup analysis did not change these results. We could not perform meta-analyses for SSSI or DSSI as these outcomes were not reported separately. Twenty-two studies related to hernioplasty surgery (total of 6443 participants) and we analysed three outcomes: SSSI; DSSI; SSSI + DSSI. Within the low infection risk environment subgroup, antibiotic prophylaxis as compared to placebo probably makes little or no difference for the outcomes 'prevention of all wound infections' (RR 0.71, 95% CI 0.44 to 1.14; moderate-quality evidence) and 'prevention of SSSI' (RR 0.71, 95% CI 0.44 to 1.17, moderate-quality evidence). Within the high infection risk environment subgroup it is uncertain whether antibiotic prophylaxis reduces all types of wound infections (RR 0.58, 95% CI 0.43 to 0.77, very low quality evidence) or SSSI (RR 0.56, 95% CI 0.41 to 0.77, very low quality evidence). When combining participants from both subgroups, antibiotic prophylaxis as compared to placebo probably reduces the risk of all types of wound infections (RR 0.61, 95% CI 0.48 to 0.78) and SSSI (RR 0.60, 95% CI 0.46 to 0.78; moderate-quality evidence). Antibiotic prophylaxis as compared to placebo probably makes little or no difference in reducing the risk of postoperative DSSI (RR 0.65, 95% CI 0.26 to 1.65; moderate-quality evidence), both in a low infection risk environment (RR 0.67, 95% CI 0.11 to 4.13; moderate-quality evidence) and in the high infection risk environment (RR 0.64, 95% CI 0.22 to 1.89; low-quality evidence).

Authors' conclusions: Evidence of very low quality shows that it is uncertain whether antibiotic prophylaxis reduces the risk of postoperative wound infections after herniorrhaphy surgery. Evidence of moderate quality shows that antibiotic prophylaxis probably makes little or no difference in preventing wound infections (i.e. all wound infections, SSSI or DSSI) after hernioplasty surgery in a low infection risk environment. Evidence of low quality shows that antibiotic prophylaxis in a high-risk environment may reduce the risk of all wound infections and SSSI, while evidence of very low quality shows that it is uncertain whether antibiotic prophylaxis reduces DSSI after hernioplasty surgery.

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Conflict of interest statement

Claudia Orelio: None known.

Coen van Hessen: None known.

Francisco Javier Sanchez‐Manuel: None known.

Theodorus Aufenacker: None known.

Rob Scholten: None known.

Figures

1
1
Study flow diagram.
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
3
3
Forest plot of comparison antibiotic prophylaxis against placebo for preventing all types of wound infection (SSSI and DSSI) after herniorrhaphy surgery.
4
4
Forest plot of comparison antibiotic prophylaxis against placebo for preventing all types of wound infection (SSSI and DSSI) after hernioplasty surgery.
5
5
Forest plot of comparison antibiotic prophylaxis against placebo for preventing superficial wound infection (SSSI) after hernioplasty surgery.
6
6
Forest plot of comparison antibiotic prophylaxis against placebo for preventing deep wound infections (DSSI) after hernioplasty surgery.
1.1
1.1. Analysis
Comparison 1: Wound infections herniorrhaphy, Outcome 1: All wound infections (SSSI+DSSI)
2.1
2.1. Analysis
Comparison 2: Wound infections hernioplasty, Outcome 1: All wound infections (SSSI+DSSI)
2.2
2.2. Analysis
Comparison 2: Wound infections hernioplasty, Outcome 2: Superficial Surgical Site Infections (SSSI)
2.3
2.3. Analysis
Comparison 2: Wound infections hernioplasty, Outcome 3: Deep Surgical Site Infections (DSSI)
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References

References to studies included in this review

Al‐Fatah 2011 {published data only}
    1. Al-Fatah, MA. The role of antibiotic prophylaxis in prevention of wound infection after Lichtenstein repair of primary inguinal hernia. Al-Azhar Assiut Medical journal 2011;9(1):173-80.
Andersen 1980 {published data only}
    1. Andersen JR, Burcharth F, Larsen HW, Roder O, Andersen B. Polyglycolic acid, silk, and topical ampicillin. Their use in hernia repair and cholecystectomy. Arch Surg 1980;115:293-5. - PubMed
Aufenacker 2004 {published data only}
    1. Aufenacker TJ, Geldere D, Mesdag T, Bossers AN, Dekker B, Scheije E et al. The role of antibiotic prophylaxis in prevention of wound infection after Lichtenstein open mesh repair of primary inguinal hernia. A multicenter double-blind randomized controlled trial. Annals of Surgery 2004;240(6):955-61. - PMC - PubMed
Bidhur 2013 {published data only}
    1. Bidhur KC, Regmi R, Agrawal CS, Pathania, OP. Role of single dose antibiotic prophylaxis in prevention of wound infection following lichtenstein inguinal hernioplasty; a randomized clinical trial. Nepal Journal of Medical Sciences December 2013;2(2):108-13.
Celdran 2004 {published data only}
    1. Celdran A, Frieyro O, la Pinta JC, Souto JL, Esteban J, Rubio JM et al. The role of antibiotic prophylaxis on wound infection after mesh hernia repair under local anaesthesia on an ambulatory basis. Hernia 2004;8(1):20-2. - PubMed
Ergul 2011 {published data only}
    1. Ergul Z, Akinci M, Urgulu C, Kulacoglu H, Yilmaz KB. Prophylactic antibiotic use in elective inguinal hernioplasty in a trauma center. Hernia 2012;16(2):145-51. - PubMed
    1. Ergul Z. Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias. Clinicaltrials.gov 2010. [NCT01264003]
    1. Kulacoglu H. The possible benefit of prophylactic antibiotic use in patients undergoing unilateral elective inguinal hernia repair with prosthetic material.. ISRCTNregistry 2010. [ISRCTN85660082]
Evans 1973 {published data only}
    1. Evans C, Pollock AV. The reduction of surgical wound infections by prophylactic parenteral cephaloridine. A controlled clinical trial. British Journal of Surgery 1973;60(6):434-7. - PubMed
Goyal 2011 {published data only}
    1. Goyal A, Garg R, Jenaw RK, Jindal DK. Role of Prophylactic Antibiotics in Open Inguinal Hernia Repair: A Randomised Study. Indian J Surg 2011;73(3):190-193. - PMC - PubMed
Ijaz 2010 {published data only}
    1. Ijaz A, Amer SM. Postopereative wound infection; Prevention "The role of antibiotic prophylaxis in Lichtenstein". Professional Medical Journal 2010;17(2):174-9.
Jain 2008 {published data only}
    1. Jain SK, Jayant M, Norbu C. The role of antibiotic prophylaxis in mesh repair of primary inguinal hernias using prolene hernia system: a randomized prospective double-blind control trial. Tropical Doctor 2008;38(2):80-2. - PubMed
Kochhar 2014 {published data only}
    1. Kochhar G, Andley M, Saha S, Kumar A, Pusuluri R, Saurabh G, A Kumar. Randomized controlled trial to evaluate the role of antibiotic prophylaxis in lichtenstein hernia repair. Journal of Young Medical Researchers 2014;1(2):1-8.
Lazorthes 1992 {published data only}
    1. Lazorthes F, Chiotasso P, Massip P, Materre JP, Sarkissian M. Local antibiotic prophylaxis in inguinal hernia repair. Surgery, Gynecology & Obstetrics 1992;175(6):569-70. - PubMed
Mazaki 2013 {published data only}
    1. Mazaki T, Mado K, Masuda H, Shiono M, Tochikura N, Kaburagi M. A randomized trial of antibiotic prophylaxis for the prevention of surgical site infection after open mesh-plug hernia repair. American Journal of Surgery 2013;207(4):476-84. - PubMed
    1. Mazaki T. Prophylactic Antibiotic Use in Hernioplasty (RCT-herniation). ClinicalTrials.gov 2008. [NCT00636831]
Morales 2000 {published data only}
    1. Morales R, Carmona A, Pagán A, García Menéndez C, Bravo R, Hernández MJ et al. Utility of antibiotic prophylaxis in reducing wound infection in inguinal or femoral hernia repair using polypropylene mesh [Utilidad de la profilaxis antibiótica en la reducción de la infección de herida en la reparación de la hernia inguinal o crural mediante malla de polipropileno]. Cirugia Espanola 2000;67(1):51-9.
Oteiza 2004 {published data only}
    1. Oteiza F, Ciga MA, Ortiz H. Antibiotic prophylaxis in inguinal hernioplasty [Profilaxis antibiótica en la hernioplastia inguinal]. Cirugia Espanola 2004;75(2):69-71.
Othman 2011 {published data only}
    1. Othman I. Prospective randomized evaluation of prophylactic antibiotic usage in patients undergoing tension free inguinal hernioplasty. Hernia 2011;15(3):309-13. - PubMed
Perez 2005 {published data only}
    1. Perez AR, Roxas MF, Hilvano SS. A randomized, double-blind, placebo-controlled trial to determine effectiveness of antibiotic prophylaxis for tension-free mesh herniorrhaphy. Journal of the American College of Surgeons 2005;200(3):393-7. - PubMed
Platt 1990 {published data only}
    1. Platt R, Zaleznik DF, Hopkins CC, Dellinger EP, Karchmer AW, Bryan CS et al. Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery. New England Journal of Medicine 1990;322(3):153-60. - PubMed
Rahmani 2012 {published data only}
    1. Kermansaravi M, Rahmani N. Evaluation of prophylactic antibiotic effectiveness in prevention of wound infection in lichtenstein hernioplasty with mesh.. IRCT 2012. [IRCT201203121786N4]
    1. Rahmani N, Saravi MK, Sayadi S, Khalilian A. Effect of prophylactic antibiotics in preventing wound infection in hernioplasty with inguinal mesh in Lichtenstein method. Journal of Mazandaran University of Medical Sciences 2012;22(90):88-93.
Razack 2015 {published data only}
    1. Razack A, Kapoor KK, Tambat RM. The role of single dose antibiotic prophylaxis in open mesh repair of inguinal hernia:a prospective, double blind randomized trial. Journal of Evolution of Medical and Dental Sciences 2015;4(35):6017-26.
Shankar 2010 {published data only}
    1. Shankar VG, Srinivasan K, Sistla SC, Jagdish S. Prophylactic antibiotics in open mesh repair of inguinal hernia. A randomized controlled trial. International Journal of Surgery (London, England) 2010;8(6):444-7. - PubMed
Taylor 1997 {published data only}
    1. Taylor EW, Byrne DJ, Leaper DJ, Karran SJ, Browne MK, Mitchell KJ. Antibiotic prophylaxis and open groin hernia repair. World Journal of Surgery 1997;21(8):811-5. - PubMed
Thakur 2010 {published data only}
    1. Thakur L, Upadhyay S, Peters NJ, Saini N, Deodhar M. Prophylactic antibiotic usage in patients undergoing inguinal mesh hernioplasty – A clinical study. Indian Journal of Surgery 2010;72(3):240-2. - PMC - PubMed
Tzovaras 2007 {published data only}
    1. Tzovaras G, Delikoukos S, Christodoulides G, Spyridakis M, Mantzos F, Tepetes K, et al. The role of antibiotic prophylaxis in elective tension-free mesh inguinal hernia repair: results of a single-centre prospective randomised trial. International Journal of Clinical Practice 2007;61(2):236-9. - PubMed
Ullah 2013 {published data only}
    1. Ullah B, Khan SA, Ahmed S, Pasha T. Efficacy of preoperative single dose antibiotic in patients undergoing mesh repair for inguinal hernia. Journal of Ayub Medical College, Abbottabad 2013;25(1-2):103-5. - PubMed
Wang 2013 {published data only}
    1. Wang J, Ji G, Yang Z, Xi M, Wu Y, Zhao P, Wang L, Yu W, Wen A. Prospective randomized, double-blind, placebo controlled trial to evaluate infection prevention in adult patients after tension-free inguinal hernia repair. International Journal of Clinical Pharmacology and Therapeutics 2013;51(12):924-31. - PubMed
    1. Wen A. Factors Related to Infection Prevention After Tension-free Inguinal Hernia Repair (infection). Clinicaltrials.gov 2013. [NCT01802606]
Yerdel 2001 {published data only}
    1. Yerdel MA, Akin EB, Dolalan S, Turkcapar AG, Pehlivan M, Gecim IE, et al. Effect of single-dose prophylactic ampicillin and sulbactam on wound infection after tension-free inguinal hernia repair with polypropylene mesh: the randomized, double-blind, prospective trial. Annals of Surgery 2001;233(1):26-33. - PMC - PubMed

References to studies excluded from this review

Ahmed 2014 {published data only}
    1. Ahmed QJ, Suchdev SD, Anwar MA, Hasan A, Sarfaraz. To detect the use of prophylactic antibiotics in inguinal hernia repair: A randomized study in tertiary care hospital Karachi. Pakistan Journal of Medical and Health Sciences 2014;8(4):976-978.
Aufenacker 2006 {published data only}
    1. Aufenacker, TJ, Koelemay, MJ, Gouma, DJ, Simons, MP. Systematic review and meta-analysis of the effectiveness of antibiotic prophylaxis in prevention of wound infection after mesh repair of abdominal wall hernia. British Journal of Surgery 2006;93(1):5-10. - PubMed
Barreca 2000 {published data only}
    1. Barreca M, Stipa F, Cardi E, Bianchini L, Lucandri G, Randone B. Antibiotic prophylaxis in the surgical treatment of inguinal hernia: need or habit? Minerva Chirurgica 2000;55(9):599-605. - PubMed
Bhuiyan 2017 {published data only}
    1. Bhuiyan MNA. Efficacy of single dose antibiotic prophylaxis in open tension free mesh inguinal hernioplasty. In: British Journal of Surgery: Association of Surgeons of Great Britain & Ireland (ASBGI) 2017. Vol. 104. 2017:185.
Boonchan 2017 {published data only}
    1. Boonchan T, Wilasrusmee C, McEvoy M, Attia J, Thakkinstian A. Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery. British Journal of Surgery 2017;104(2):e106-e117. - PMC - PubMed
Erdas 2016 {published data only}
    1. Erdas E, Medas F, Pisano G, Nicolosi A, Calo PG. Antibiotic prophylaxis for open mesh repair of groin hernia: systematic review and meta-analysis. Hernia 2016;20(6):765-76. - PubMed
Esposito 2006 {published data only}
    1. Esposito S, Leone S, Noviello S, Ianniello S, Marvaso F, Cuniato A, et al. Antibiotic prophylaxis in hernia repair and breast surgery: A prospective randomized study comparing piperacillin/tazobactam versus placebo. Journal of Chemotherapy (Florence, Italy) 2006;18(3):278-284. - PubMed
Gierhake 1975 {published data only}
    1. Gierhake FW. [Antibiotics and their indications in surgery]. Der Chirurg; Zeitschrift fur Alle Gebiete der Operativen Medizen 1975;46(1):10-5. - PubMed
Lazorthes 1993 {published data only}
    1. Lazorthes F, Chiotasso P, Massip P, Materre JP, Sarkissian M. Prophylaxis of infection at site of inguinal hernia repair of pre-operative local antibiotic administration [French]. Journal de Chirurgie 1993;130(12):507-9. - PubMed
Leon 2011 {published data only}
    1. Leon JS, Acevedo AF, Riosecor DR, Vasquez JV, Dellepiane VEU. Antibiotic prophylaxis in mesh inguinal herniorrhapy. Revista Chilena De Cirugia 2011;63(2):186-90. [DOI: ]
Li 2012 {published data only}
    1. Li J-F, Lai D-D, Zhang X-D, Zhang A-M, Sun K-X, Luo H-G, et al. Meta-analysis of the effectiveness of prophylactic antibiotics in the prevention of postoperative complications after tension-free hernioplasty. Canadian Journal of Surgery 2012;55(1):27-32. - PMC - PubMed
Mazaki 2013b {published data only}
    1. Mazaki T, Mado K, Masuda H, Shiono M. Antibiotic prophylaxis for the prevention of surgical site infection after tension-free hernia repair: a Bayesian and frequentist meta-analysis. Journal of the American College of Surgeons 2013;217(5):788-801. - PubMed
Mehrabi Bahar 2015 {published data only}
    1. Mehrabi Bahar M, Jabbari Nooghabi A, Jabbari Nooghabi M, Jangjoo A. The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh. Asian Journal of Surgery 2015;38(3):139-44. - PubMed
Pessaux 2006 {published data only}
    1. Pessaux P, Lermitte E, Blezel E, Msika S, Hay J-M, Flamant Y, et al. Predictive risk score for infection after inguinal hernia repair. American Journal of Surgery 2006;192(2):165-71. - PubMed
Sanabria 2007 {published data only}
    1. Sanabria A, Dominguez LC, Valdivieso E, Gomez G. Prophylactic antibiotics for mesh inguinal hernioplasty: a meta-analysis. Annals of Surgery 2007;245(3):392-6. - PMC - PubMed
Sanchez‐Manuel 2003 {published data only}
    1. Sanchez-Manuel FJ, Seco-Gil JL. Antibiotic prophylaxis for hernia repair. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No: CD003769. [DOI: 10.1002/14651858.CD003769] - DOI - PubMed
Sanchez‐Manuel 2012 {published data only}
    1. Sanchez-Manuel JF, Lozano-Garcia J, Seco-Gil JL. Antibiotic prophylaxis for hernia repair. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No: CD003769. [DOI: 10.1002/14651858.CD003769.pub4] - DOI - PMC - PubMed
Taylor 1996 {published data only}
    1. Taylor EW, Byrne D, Karran S, Leaper D, Browne MK, Mitchell KG. Is antibiotic prophylaxis indicated for open groin hernia repair? British Journal of Surgery 1996;83(S2):61. - PubMed
Yin 2012 {published data only}
    1. Yin Y, Song T, Liao B, Luo Q, Zhou Z. Antibiotic prophylaxis in patients undergoing open mesh repair of inguinal hernia: a meta-analysis. American Surgeon 2012;78(3):359-65. - PubMed

References to studies awaiting assessment

Additional references

Altman 1991
    1. Altman DG. Practical Statistics for medical Research. Chapman & Hall, 1991.
Bailey 1992
    1. Bailey IS, Karran SE, Toyn K, Brough P, Ranaboldo C, Karran SJ. Community surveillance of complications after hernia surgery. BMJ 1992;304(6825):469-71. - PMC - PubMed
Bassini 1890
    1. Bassini E. [About the treatment of inguinal hernia] [Ueber die Behandlung des Leistenbruches]. Langenbecks Arch Klin Chir 1890;40:429-76.
Berard 1964
    1. Berard F, Gandon J (National Academy of Sciences, National Research Council, Division of Medical Sciences, Ad Hoc Committee on Trauma). Postoperative wound infections: the influence of ultraviolet irradiation on the operating room and of various other factors. Annals of Surgery 1964;160(Suppl 2):1-192. - PubMed
Berrios‐Torres 2017
    1. Berrios-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al, Healthcare Infection Control Practices Advisory Committee. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surgery 2017;152(8):784-91. - PubMed
Biswas 2005
    1. Biswas S. Elective inguinal hernia repair with mesh: is there need for antibiotic prophylaxis? A review. World Journal of Surgery 2005;29(7):830-6. - PubMed
Bluebelle Study Group 2018
    1. Bluebelle Study Group. Validation of the Bluebelle Wound Healing Questionnaire for assessment of surgical-site infection in closed primary wounds after hospital discharge. British Journal of Surgery 2018;106(3):226-35. - PMC - PubMed
Bratzler 2013
    1. Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surgical Infections 2013;14(1):73-156. - PubMed
Cai 2018
    1. Cai LZ, Foster D, Kethman WC, Weiser TG, Forrester JD. Surgical Site Infections after InguinalHernia Repairs Performed in Low- and Middle-Human Development Index Countries:A Systematic Review. Surgical Infections 2018;19(1):11-20. - PubMed
Cainzos 1990
    1. Cainzos M, Lozano F, Balibrea JL, Dávila D, Potel J, Gómez Alonso A, et al. Postoperative infection: multicentric, prospective and controlled study [La infección postoperatoria: estudio multicéntrico, prospectivo y controlado]. Cirugia Espanola 1990;48(5):481-90.
Chokshi 2019
    1. Chokshi A, Sifri Z, Cennimo D, Horng H. Global contributors to antibiotic resistance. Journal of Global Infectious Diseases 2019;11(1):36-42. - PMC - PubMed
Codina 1999
    1. Codina C, Trilla A, Riera N, Tuset M, Carne X, Ribas J, et al. Perioperative antibiotic prophylaxis in Spanish hospitals: results of a questionnaire survey. Infection Control and Hospital Epidemiology 1999;20(6):436-9. - PubMed
Condon 1991
    1. Condon RE, Wittmann DH. The use of antibiotics in general surgery. Current Problems in Surgery 1991;28(12):803-907. - PubMed
Covidence [Computer program]
    1. Covidence. Version accessed April to August 2018. Melbourne, Australia: Veritas Health Innovation. Available at covidence.org.
Dellinger 1994
    1. Dellinger EP, Gross PA, Barrett TL, Krause PJ, Martone WJ, McGowan JE, et al. Quality standard for antimicrobial prophylaxis in surgical procedures. Clinical Infectious Diseases 1994;18(3):422-7. - PubMed
Dindo 2004
    1. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Annals of Surgery 2004;240(2):205-13. - PMC - PubMed
EUCAST System for Antimicrobial Abbreviations
    1. EUCAST. EUCAST System for Antimicrobial Abbreviations. www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Disk_test_documents... July 2018.
Fawole 2006
    1. Fawole AS, Chaparala RP, Ambrose NS. Fate of the inguinal hernia following removal of infected prosthetic mesh. Hernia 2006;10(1):58-61. - PubMed
Finan 2005
    1. Finan KR, Vick CC, Kiefe CI, Neumayer L, Hawn MT. Predictors of wound infection in ventral hernia repair. American Journal of Surgery 2005;190(5):676-81. - PubMed
Finch 2019
    1. Finch DA, Misra VA, Hajibandeh S. Open darn repair vs open mesh repair of inguinal hernia: a systematic review and meta-analysis of randomised and non-randomised studies. Hernia 2019;23(3):523-39. - PubMed
Fitzgibbons 2013
    1. Fitzgibbons RJ, Ramanan B, Arya S, Turner SA, Li X, Gibbs JO, et al, Investigators of the Original Trial. Long-term results of a randomized controlled trial of a non-operative strategy (watchful waiting) for men with minimally symptomatic inguinal hernias. Annals of Surgery 2013;258(3):508-15. - PubMed
Fitzgibbons 2015
    1. Fitzgibbons RJ, Armour Forse R. Groin hernias in adults. New England Journal of Medicine 2015;372(8):756-63. - PubMed
Gilbert 1989
    1. Gilbert AI. An anatomic and functional classification for the diagnosis and treatment of inguinal hernia. American Journal of Surgery 1989;157(3):331-3. - PubMed
GlobalSurg Collaborative 2018
    1. GlobalSurg Collaborative. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infectious Diseases 2018;18(5):516-25. - PMC - PubMed
GRADE pro GDT [Computer program]
    1. GRADE proGDT. Version accessed December 2018. Hamilton (ON): McMaster University (developed by Evidence Prime), 2015. Available at gradepro.org.
Haley 1985
    1. Haley RW, Culver DH, Morgan WM, White JW, Emori TG, Hooton TM. Identifying patients at high risk of surgical wound infection. American Journal of Epidemiology 1985;121(2):206-15. - PubMed
Heineck 1999
    1. Heineck I, Ferreira MB, Schenkel EP. Prescribing practice for antibiotic prophylaxis for 3 commonly performed surgeries in a teaching hospital in Brazil. American Journal of Infection Control 1999;27(3):296-300. - PubMed
HerniaSurge Group 2018
    1. HerniaSurge Group. International guidelines for groin hernia management. Hernia 2018;22(1):1-165. - PMC - PubMed
Higgins 2016
    1. Higgins JP, Lasserson T, Chandler J, Tovey, D, Churchill R. Methodological Expectations of Cochrane Intervention Reviews (MECIR). community.cochrane.org/sites/default/files/uploads/MECIR%20PRINTED%20BOO... (accessed prior to 15 January 2020).
Higgins 2017
    1. Higgins JP, Altman DG, Sterne JA, editor(s). Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Churchill R, Chandler J, Cumpston MS, editor(s), Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0 (updated June 2017). The Cochrane Collaboration, 2017. Available from www.training.cochrane.org/handbook.
Holmes 1994
    1. Holmes J, Readman R. A study of wound infections following inguinal hernia repair. Journal of Hospital Infection 1994;28(2):153-6. - PubMed
Horan 1992
    1. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infection Control and Hospital Epidemiology 1992;13(10):606-8. - PubMed
Johanet 2011
    1. Johanet H, Contival N, Coelio Club. Mesh infection after inguinal hernia repair. Journal of Visceral Surgery 2011;148(5):e392-e394. - PubMed
Kingsnorth 2003
    1. Kingsnorth A, LeBlanc K. Hernias: inguinal and incisional. Lancet 2003;362(9395):1561-71. - PubMed
Kurzer 1998
    1. Kurzer M, Belsham PA, Kark AE. The Lichtenstein repair. Surgical Clinics of North America 1998;78(6):1025-46. - PubMed
Lagace‐Wiens 2012
    1. Lagace-Wiens P, Rubinstein E. Adverse reactions to betalactam antimicrobials. Expert Opinion on Drug Safety 2012;11(3):381–99. - PubMed
Leaper 1998
    1. Leaper DJ. Use of antibiotic prophylaxis in clean non-implant wounds. Journal of Antimicrobial Chemotherapy 1998;41(5):501-4. - PubMed
Lichtenstein 1989
    1. Lichtenstein IL, Shulman AG, Amid PK, Montllor MM. The tension-free hernioplasty. American Journal of Surgery 1989;157(2):188-93. - PubMed
Mandell 2010
    1. Mandell GL, Bennett JE, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th edition. Churchill Livingstone Elsevier, 2010.
Mangram 1999
    1. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR, The Hospital Infection Control Practices Advisory Committee. Guideline for prevention of surgical site infection, 1999. Infection Control and Hospital Epidemiology 1999;20(4):247-78. - PubMed
Mann 1998
    1. Mann DV, Prout J, Havranek E, Gould S, Darzi A. Late-onset deep prosthetic infection following mesh repair of inguinal hernia. American Journal of Surgery 1998;176(1):12-4. - PubMed
Miserez 2014
    1. Miserez M, Peeteres E, Aufenacker T, Bouillot JL, Campanelli G, Conze J, et al. Update with level 1 studies of the European Hernia Society guidelines on the treatment of inguinal hernia in adult patients. Hernia 2014;18(2):151-63. - PubMed
Mozillo 1988
    1. Mozillo N, Greco D, Pescini A, Formato A. Chemoprophylaxis in the surgical ward: results of a national survey in Italy. European Journal of Epidemiology 1988;4(3):357-9. - PubMed
Ortega 2012
    1. Ortega G, Rhee DS, Papandria DJ, Yang J, Ibrahim AM, Shore AD, et al. An evaluation of surgical site infections by wound classification system using the ACS-NSQIP. Journal of Surgical Research 2012;174(1):33-8. - PubMed
Page 1993
    1. Page CP, Bohnen JMA, Fletcher JR, MacManus AT, Solomkin JS, Wittmann DH. Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care. Archives of Surgery 1993;128(1):79-88. - PubMed
Porcu 1996
    1. Porcu A, Noya G, Dessanti A, Niolu P, Cottu P, Castiglia P, et al. A new approach to the problem of surgical wound infections in clean operations. Minerva Chirurgica 1996;51(9):691-6. - PubMed
Ranaboldo 1993
    1. Ranaboldo CJ, Karran SE, Bailey S, Karran SJ. Antimicrobial prophylaxis in clean surgery: hernia repair. Journal of Antimicrobial Chemotherapy 1993;31(Suppl B):35-41. - PubMed
Rehman 2012
    1. Rehman S, Khan S, Pervaiz A, Perry EP. Recurrence of inguinal herniae following removal of infected prosthetic meshes: a review of the literature. Hernia 2012;16(2):123-6. - PubMed
Review Manager 2014 [Computer program]
    1. Review Manager 5 (RevMan 5). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Robbins 1998
    1. Robins AW, Rutkow IM. Mesh plug repair and groin hernia surgery. Surgical Clinics of North America 1998;78(6):1007-23. - PubMed
Rodriguez 2005
    1. Rodriguez-Cuellar E, Villeta R, Ruiz P, Alcalde J, Landa JI, Porrero JL, et al. National project for the management of clinical processes. Surgical treatment of inguinal hernia [Proyecto nacional para la gestión clínica de procesos asistenciales. Tratamiento quirúrgico de la hernia inguinal]. Cirugia Espanola 2005;77(4):194-202. - PubMed
Rutkow 1993
    1. Rutkow IM, Robbins AW. 'Tension-free' inguinal herniorrhaphy: a preliminary report on the 'mesh-plug' technique. Surgery 1993;114(1):3-8. - PubMed
Rutkow 2003
    1. Rutkow IM. Demographic and socio-economic aspects of hernia repair in the United States in 2003. Surgical Clinics of North America 2003;83(5):1045-51. - PubMed
Simons 2009
    1. Simons MP, Aufenacker T, Bay-Nielsen M, Bouillot JL, Campanelli G, Conze J, et al. European Hernia Society guidelines on the treatment of inguinal hernia in adult patients. Hernia 2009;13(4):343-403. - PMC - PubMed
Stephenson 2003
    1. Stephenson BM. Complications of open groin hernia. Surgical Clinics of North America 2003;83(5):1255-78. - PubMed
Wittmann 1995
    1. Wittmann DH, Schein M, Condon RE. Antibiotic prophylaxis in abdominal wall hernia surgery: never, always, or selectively? Problems in General Surgery 1995;12(1):47-55.
Woods 1998
    1. Woods RK, Dellinger EP. Current guidelines for antibiotic prophylaxis of surgical wounds. American Family Physician 1998;58(11):2731-40. - PubMed
Zollinger 2003
    1. Zollinger RM. Classification systems for groin hernias. Surgical Clinics of North America 2003;83(5):1053-63. - PubMed

References to other published versions of this review

Sanchez‐Manuel 2001
    1. Sánchez-Manuel FJ, Seco-Gil JL, Lozano-García J. Antibiotic prophylaxis and hernia repair. Systematic quantitative review results [Profilaxis antibiótica y reparación herniaria. Resultado de una revisión sistemática cuantitativa.]. Enfermedades Infecciosas y Microbiologia Clinica 2001;19(3):107-13. - PubMed
Sanchez‐Manuel 2003
    1. Sánchez-Manuel FJ, Seco-Gil JL. Antibiotic prophylaxis for hernia repair. Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No: CD003769. [DOI: 10.1002/14651858.CD003769] - DOI - PubMed
Sanchez‐Manuel 2004
    1. Sánchez-Manuel FJ, Seco-Gil JL. Antibiotic prophylaxis for hernia repair. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No: CD003769. [DOI: 10.1002/14651858.CD003769.pub2] - DOI - PubMed
Sanchez‐Manuel 2007
    1. Sánchez-Manuel FJ, Lozano-García J, Seco-Gil JL. Antibiotic prophylaxis for hernia repair. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No: CD003769. [DOI: 10.1002/14651858.CD003769.pub3] - DOI - PubMed
Sanchez‐Manuel 2012
    1. Sánchez-Manuel FJ, Lozano-García J, Seco Gil JL. Antibiotic prophylaxis for hernia repair. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No: CD003769. [DOI: 10.1002/14651858.CD003769.pub4] - DOI - PMC - PubMed

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