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. 2020 Apr 1;16(4):e1008702.
doi: 10.1371/journal.pgen.1008702. eCollection 2020 Apr.

Getting clear about the F-word in genomics

Stefan Linquist  1 , W Ford Doolittle  2 , Alexander F Palazzo  3
Affiliations

Getting clear about the F-word in genomics

Stefan Linquist et al. PLoS Genet. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A simple case of Constructive Neutral Evolution.
As Lambowitz and colleagues have shown [18], some strains of Neurospora crassa sport, in their mitochondrial rRNA genes, a group I intron which, because of its structure, is able to carry out a necessary interaction (self-splicing) without assistance of any protein. But in other strains, an unrelated protein fortuitously binds to and stabilizes the intron RNA. Destabilizing mutations in the RNA’s structure that would render it incapable of self-splicing without the bound protein are permitted ("pre-suppressed"). Such mutations are occasionally fixed by drift, and when more than one such mutation is possible, it is rare to reverse them all. Dependence on an assisting protein, initially a "pre-suppressor" of such mutations, is effectively locked-in.
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References

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Grants and funding

Financial support for this research was provided by the Social Sciences and Humanities Research Council of Canada (https://www.sshrc-crsh.gc.ca/, grant #430335) to Stefan Linquist and by the Natural Sciences and Engineering Research Council of Canada (nserc-crsng.gc.ca, grant # GLDSU44989) to W. Ford Doolittle. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.