The molecular evolution of genes and proteins: a tale of two serines
- PMID: 3136396
- DOI: 10.1038/334528a0
The molecular evolution of genes and proteins: a tale of two serines
Abstract
The advent of techniques for cloning and rapidly sequencing DNA has produced an explosive increase of sequence information for nucleic acids and their inferred proteins. Careful study of this large store of data might give us new insights into the relations between the linear sequences of genes and their functions embodied in the three-dimensional structure of proteins, and also illuminate the origin and evolution of the structural complexity of present-day proteins. Here I argue from such a study that the active site sequences of enzymes that have analogous essential serine residues lie in fact on two lines of descent from an ancient ancestral enzyme which had a cysteine instead of serine in its active site. This is based on the assumption that the two codon types which define the separate lines of descent and which have different bases in two positions could not interconvert by single mutations.
Similar articles
-
Genetic studies of the lac repressor. XIV. Analysis of 4000 altered Escherichia coli lac repressors reveals essential and non-essential residues, as well as "spacers" which do not require a specific sequence.J Mol Biol. 1994 Jul 29;240(5):421-33. doi: 10.1006/jmbi.1994.1458. J Mol Biol. 1994. PMID: 8046748
-
[Analysis, identification and correction of some errors of model refseqs appeared in NCBI Human Gene Database by in silico cloning and experimental verification of novel human genes].Yi Chuan Xue Bao. 2004 May;31(5):431-43. Yi Chuan Xue Bao. 2004. PMID: 15478601 Chinese.
-
Rates of transition and transversion in coding sequences since the human-rodent divergence.Genomics. 1994 Apr;20(3):386-96. doi: 10.1006/geno.1994.1192. Genomics. 1994. PMID: 8034311
-
GDSL family of serine esterases/lipases.Prog Lipid Res. 2004 Nov;43(6):534-52. doi: 10.1016/j.plipres.2004.09.002. Prog Lipid Res. 2004. PMID: 15522763 Review.
-
Proteolytic enzymes, past and present.Fed Proc. 1985 Nov;44(14):2907-13. Fed Proc. 1985. PMID: 2996945 Review.
Cited by
-
A random mutagenesis screen enriched for missense mutations in bacterial effector proteins.G3 (Bethesda). 2024 Sep 4;14(9):jkae158. doi: 10.1093/g3journal/jkae158. G3 (Bethesda). 2024. PMID: 39028840 Free PMC article.
-
Unraveling the complexity of human brain: Structure, function in healthy and disease states.Ageing Res Rev. 2024 Sep;100:102414. doi: 10.1016/j.arr.2024.102414. Epub 2024 Jul 15. Ageing Res Rev. 2024. PMID: 39002647 Review.
-
Codon switching of conserved Ser residues in coagulation and fibrinolytic proteases.J Thromb Haemost. 2024 Sep;22(9):2495-2501. doi: 10.1016/j.jtha.2024.05.021. Epub 2024 May 29. J Thromb Haemost. 2024. PMID: 38821294
-
FireProt 2.0: web-based platform for the fully automated design of thermostable proteins.Brief Bioinform. 2023 Nov 22;25(1):bbad425. doi: 10.1093/bib/bbad425. Brief Bioinform. 2023. PMID: 38018911 Free PMC article.
-
Recent advances in the production, properties and applications of haloextremozymes protease and lipase from haloarchaea.World J Microbiol Biotechnol. 2023 Sep 27;39(11):322. doi: 10.1007/s11274-023-03779-x. World J Microbiol Biotechnol. 2023. PMID: 37755613 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
