iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://pubmed.ncbi.nlm.nih.gov/30376840
Dietary fiber intake and reduced risk of ovarian cancer: a meta-analysis - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Oct 30;17(1):99.
doi: 10.1186/s12937-018-0407-1.

Dietary fiber intake and reduced risk of ovarian cancer: a meta-analysis

Bowen Zheng  1 , Hui Shen  2 , Hedong Han  3 , Ting Han  4 , Yonghong Qin  5
Affiliations
Meta-Analysis

Dietary fiber intake and reduced risk of ovarian cancer: a meta-analysis

Bowen Zheng et al. Nutr J. .

Abstract

Background: Epidemiological studies regarding the association between dietary fiber intake and ovarian cancer risk are still inconsistent. We aimed to review the available evidence and conduct a dose-response meta-analysis to investigate the relationship between dietary fiber intake and ovarian cancer risk.

Methods: Relevant studies were identified by searching PubMed, EMBASE, and the Cochrane Library databases before August 2017. Studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between dietary fiber intake and risk of ovarian cancer were included. Random-effects models were used to combine the estimated effects extracted from individual study.

Results: Thirteen studies, with a total of 5777 ovarian cancer cases and 142,189 participants, met the inclusion criteria. The pooled multivariable RRs of ovarian cancer for the highest vs. the lowest category of dietary fiber intake was 0.78 (95% CI: 0.70, 0.88) with no evidence of heterogeneity (I2 = 4.20%, P = 0.40). Our dose-response analysis also showed a significant inverse association between dietary fiber intake and ovarian cancer risk (an increment of 10 g/day; combined RR: 0.88; 95% CI: 0.82, 0.93). There was no evidence for a nonlinear association (P for nonlinearity = 0.83).

Conclusions: This meta-analysis suggests a significant inverse dose-response association between dietary fiber intake and ovarian cancer risk. Further studies with prospective design that take account of more potential confounders are warranted to confirm this association.

Keywords: Dietary fiber; Meta-analysis; Ovarian cancer; Protective factor.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

All of the authors declare that they have no competing interest.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Selection of studies for inclusion in this meta-analysis
Fig. 2
Fig. 2
Forest plot of dietary fiber intake and risk of ovarian cancer for highest vs. lowest categories
Fig. 3
Fig. 3
Frost plot of relative risk of ovarian cancer for an increment of 10 g/day dietary fiber intake
Fig. 4
Fig. 4
Funnel plot of studies reporting dietary fiber intake and ovarian cancer risk
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. doi: 10.3322/caac.21262. - DOI - PubMed
    1. Falconer H, Yin L, Gronberg H, Altman D. Ovarian cancer risk after salpingectomy: a nationwide population-based study. J Natl Cancer Inst. 2015;107:dju410. doi: 10.1093/jnci/dju410. - DOI - PubMed
    1. Turati F, Galeone C, Gandini S, Augustin LS, Jenkins DJ, Pelucchi C, La Vecchia C. High glycemic index and glycemic load are associated with moderately increased cancer risk. Mol Nutr Food Res. 2015;59:1384–1394. doi: 10.1002/mnfr.201400594. - DOI - PubMed
    1. Qiu W, Lu H, Qi Y, Wang X. Dietary fat intake and ovarian cancer risk: a meta-analysis of epidemiological studies. Oncotarget. 2016;7:37390–37406. - PMC - PubMed
    1. Hedelin M, Lof M, Andersson TML, Adlercreutz H, Weiderpass E. Dietary phytoestrogens and the risk of ovarian Cancer in the Women's lifestyle and health cohort study. Cancer Epidemiol Biomark Prev. 2011;20:308–317. doi: 10.1158/1055-9965.EPI-10-0752. - DOI - PubMed

Publication types