doi: 10.1016/j.tem.2018.09.005.
Epub 2018 Oct 5.
Central Obesity, Faster Maturation, and 'PCOS' in Girls
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- PMID: 30297320
- DOI: 10.1016/j.tem.2018.09.005
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Central Obesity, Faster Maturation, and 'PCOS' in Girls
Trends Endocrinol Metab.
2018 Dec.
Abstract
Polycystic ovary syndrome (PCOS) development commonly starts with a mismatch between pre- and postnatal weight gain, leading to hepatovisceral fat excess. To escape from such central obesity, girls may accelerate their growth and/or maturation. This homeostatic mechanism is lost upon reaching adult height, and PCOS may ensue. Prevention and/or treatment of PCOS should aim at reducing central fat excess.
Keywords: fatty liver; hirsutism; maturation; ovulation; polycystic ovary syndrome; visceral fat.
Copyright © 2018 Elsevier Ltd. All rights reserved.
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