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Link to original content: https://pubmed.ncbi.nlm.nih.gov/30199223/
Development of Adenosine A2A Receptor Antagonists for the Treatment of Parkinson's Disease: A Recent Update and Challenge - PubMed Skip to main page content
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Review
. 2019 Feb 20;10(2):783-791.
doi: 10.1021/acschemneuro.8b00313. Epub 2018 Sep 21.

Development of Adenosine A2A Receptor Antagonists for the Treatment of Parkinson's Disease: A Recent Update and Challenge

Jiyue Zheng  1 , Xiaohu Zhang  1 , Xuechu Zhen  1
Affiliations
Review

Development of Adenosine A2A Receptor Antagonists for the Treatment of Parkinson's Disease: A Recent Update and Challenge

Jiyue Zheng et al. ACS Chem Neurosci. .

Abstract

Parkinson's disease (PD) is a neurodegenerative disease with significant unmet medical needs. The current dopamine-centered treatments aim to restore motor functions of patients without slowing the disease progression. Long-term usage of these drugs is associated with diminished efficacy, motor fluctuation, and dyskinesia. Furthermore, the nonmotor features associated with PD such as sleep disorder, pain, and psychiatric symptoms are poorly addressed by the dopaminergic treatments. Adenosine receptor A2A antagonists have emerged as potential treatment for PD in the past decade. Here we summarize the recent work (2015-2018) on adenosine receptor A2A antagonists and discuss the challenge and opportunity for the treatment of PD.

Keywords: Adenosine receptor; GPCR; Parkinson’s disease; antagonist.

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