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Link to original content: https://pubmed.ncbi.nlm.nih.gov/30170465
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Review
. 2018 Aug;97(35):e12179.
doi: 10.1097/MD.0000000000012179.

The association between vitamin D status and tuberculosis in children: A meta-analysis

Xiaoyun Gou  1 , Lingli Pan, Fajuan Tang, Hu Gao, Dongqiong Xiao
Affiliations
Review

The association between vitamin D status and tuberculosis in children: A meta-analysis

Xiaoyun Gou et al. Medicine (Baltimore). 2018 Aug.

Abstract

Background: Vitamin D deficiency (VDD) has been implicated in the pathogenesis of tuberculosis (TB), but most studies have not reported a significant association. We conducted a meta-analysis to explore the association between vitamin D status and TB in children.

Methods: Web of Science, Ovid Medline, and EMBASE were searched for studies in English that discussed vitamin D status and TB in children before January 22, 2018.

Results: From the 585 initially identified studies, we selected those that addressed an association between vitamin D status and TB according to our preselected inclusion criteria. Our meta-analysis included 10 studies. According to the random effects model, TB was significantly associated with VDD (ORs, 1.70; 95% CI, 1.20-2.42; P < .05) in children. Vitamin D levels were significantly lower in TB patients than in controls, with a mean difference d = -5.49 nmol/L (95% CI, -10.42 to -0.55; P < .05), indicating that VDD was significantly associated with TB (OR, 1.78; 95% CI, 1.30-2.44; P < .05) in children.

Conclusion: This study suggests that vitamin D levels are significantly lower in children with TB/latent TB infection than in controls. TB may contribute to VDD in children. Therefore, VDD may be associated with TB in children.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow chart for study selection.
Figure 2
Figure 2
Forest plot of the comparison of vitamin D levels (nmol/L) between the active TB/LTBI and control groups. LTBI = latent TB infection, TB = tuberculosis.
Figure 3
Figure 3
Forest plot of pooled odds ratios for vitamin D deficiency in the active TB/LTBI and control groups. LTBI = latent TB infection, TB = tuberculosis.
Figure 4
Figure 4
Forest plot of pooled odds ratios for tuberculosis in the vitamin D-deficient and vitamin D-sufficient groups.
See this image and copyright information in PMC

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