Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era
- PMID: 29100010
- DOI: 10.1016/j.stem.2017.09.014
Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era
Abstract
Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations from our recent fourth GForce-PD meeting.
Copyright © 2017 Elsevier Inc. All rights reserved.
Similar articles
-
Replacing what's lost: a new era of stem cell therapy for Parkinson's disease.Transl Neurodegener. 2020 Jan 7;9:2. doi: 10.1186/s40035-019-0180-x. eCollection 2020. Transl Neurodegener. 2020. PMID: 31911835 Free PMC article. Review.
-
Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease.Nat Med. 2019 Jul;25(7):1045-1053. doi: 10.1038/s41591-019-0507-2. Epub 2019 Jul 1. Nat Med. 2019. PMID: 31263283
-
Advancing Parkinson's disease treatment: cell replacement therapy with neurons derived from pluripotent stem cells.Stem Cells. 2024 Sep 10;42(9):781-790. doi: 10.1093/stmcls/sxae042. Stem Cells. 2024. PMID: 38902932 Review.
-
Clinical translation of stem cell transplantation in Parkinson's disease.J Intern Med. 2016 Jan;279(1):30-40. doi: 10.1111/joim.12415. Epub 2015 Aug 31. J Intern Med. 2016. PMID: 26332959 Review.
-
Progress in Dopaminergic Cell Replacement and Regenerative Strategies for Parkinson's Disease.ACS Chem Neurosci. 2019 Feb 20;10(2):839-851. doi: 10.1021/acschemneuro.8b00389. Epub 2018 Oct 24. ACS Chem Neurosci. 2019. PMID: 30346716 Review.
Cited by
-
Cell therapy for neurological disorders.Nat Med. 2024 Oct;30(10):2756-2770. doi: 10.1038/s41591-024-03281-3. Epub 2024 Oct 15. Nat Med. 2024. PMID: 39407034 Review.
-
Organoids and chimeras: the hopeful fusion transforming traumatic brain injury research.Acta Neuropathol Commun. 2024 Aug 30;12(1):141. doi: 10.1186/s40478-024-01845-5. Acta Neuropathol Commun. 2024. PMID: 39215375 Free PMC article. Review.
-
Immunosuppression in stem cell clinical trials of neural and retinal cell types: A systematic review.PLoS One. 2024 Jul 5;19(7):e0304073. doi: 10.1371/journal.pone.0304073. eCollection 2024. PLoS One. 2024. PMID: 38968328 Free PMC article.
-
Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson's Disease Animal Model.Life (Basel). 2024 Jun 5;14(6):728. doi: 10.3390/life14060728. Life (Basel). 2024. PMID: 38929711 Free PMC article.
-
Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies.Cells. 2024 Apr 25;13(9):745. doi: 10.3390/cells13090745. Cells. 2024. PMID: 38727281 Free PMC article. Review.
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials