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Link to original content: https://pubmed.ncbi.nlm.nih.gov/25610152/
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. 2011 Apr;43(1):9-12.
doi: 10.5152/eajm.2011.02.

The significance of serum transferrin receptor levels in the diagnosis of the coexistence of anemia of chronic disease and iron deficiency anemia

Osman Yokus  1 , Bilal Yilmaz  2 , Murat Albayrak  3 , Ozlem Sahin Balcik  4 , Mehmet Rami Helvaci  5 , Engin Sennaroglu  2
Affiliations

The significance of serum transferrin receptor levels in the diagnosis of the coexistence of anemia of chronic disease and iron deficiency anemia

Osman Yokus et al. Eurasian J Med. 2011 Apr.

Abstract
in English, Turkish

Objective: Iron deficiency anemia is the most common cause of microcytic anemia throughout the world. Ferritin levels are good indicators of iron stores; however, levels may increase irrespective of iron stores in cases of chronic disease. Therefore, it is difficult to diagnose iron deficiency anemia coexisting with anemia of chronic disease.

Materials and methods: To determine the level of transferrin receptor in subjects, 30 patients with iron deficiency anemia, 30 patients with anemia of chronic disease and 30 patients with both diseases were included in the study.

Results: Mean serum transferrin receptor levels were 5.99±2.98 mg/L in the iron deficiency anemia group, 1.90±1.15 mg/L in the anemia of chronic disease group and 3.07±0.90 mg/L in the combination group. Comparing groups with each other revealed significant differences (p<0.05).

Conclusion: It is concluded that the assessment of serum transferrin receptor levels is a useful method for the diagnosis of iron deficiency anemia in patients.

Amaç: Demir eksikliği anemisi tüm dünyada en sık görülen mikrositer anemi sebebidir. Ferritin düzeyi demir depolarının iyi bir göstergesi olmasına rağmen kronik hastalık durumlarında demir depolarından bağımsız olarak yükselebilmektedir. Bu yüzden kronik hastalık anemisiyle birlikte olan demir eksikliği anemisinin tanısını koymak zordur.

Gereç ve yöntem: Transferrin reseptör düzeyinin yararını değerlendirmek amacıyla demir eksikliği anemisi, kronik hastalık anemisi ve kombine olmak üzere her gruptan 30’ar hasta çalışmaya alındı.

Bulgular: Ortalama serum transferrin reseptör düzeyleri demir eksikliği anemisinde 5.99±2.98 mg/L, kronik hastalık anemisinde 1.90±1.15 mg/L ve kombine olan grupta ise 3.07±0.90 mg/L olarak bulundu. Gruplar birbirleri ile karşılaştırıldığında aralarında anlamlı farklılık saptandı (p<0.05).

Sonuç: Hastalarda demir eksikliği anemisini tespit etmede, serum transferrin reseptör düzeyinin değerlendirilmesinin oldukça faydalı bir yöntem olduğu sonucuna varılmıştır.

Keywords: Anemia of chronic disease; Iron deficiency anemia; Serum transferrin receptor level.

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