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. 2015 Feb;89(4):2425-9.
doi: 10.1128/JVI.02752-14. Epub 2014 Dec 3.

GB virus C coinfections in west African Ebola patients

Michael Lauck  1 , Adam L Bailey  1 , Kristian G Andersen  2 , Tony L Goldberg  3 , Pardis C Sabeti  2 , David H O'Connor  4
Affiliations

GB virus C coinfections in west African Ebola patients

Michael Lauck et al. J Virol. 2015 Feb.

Abstract

In 49 patients with known Ebola virus disease outcomes during the ongoing outbreak in Sierra Leone, 13 were coinfected with the immunomodulatory pegivirus GB virus C (GBV-C). Fifty-three percent of these GBV-C(+) patients survived; in contrast, only 22% of GBV-C(-) patients survived. Both survival and GBV-C status were associated with age, with older patients having lower survival rates and intermediate-age patients (21 to 45 years) having the highest rate of GBV-C infection. Understanding the separate and combined effects of GBV-C and age on Ebola virus survival may lead to new treatment and prevention strategies, perhaps through age-related pathways of immune activation.

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FIG 1
FIG 1
Ebola virus mortality and GBV-C coinfection status by age.
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