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Link to original content: https://pubmed.ncbi.nlm.nih.gov/24559082/
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. 2014 Feb 21:7:77.
doi: 10.1186/1756-3305-7-77.

ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe

Hein Sprong  1 , Jos Trentelman, Ingar Seemann, Libor Grubhoffer, Ryan O M Rego, Ondřej Hajdušek, Petr Kopáček, Radek Šíma, Ard M Nijhof, Juan Anguita, Peter Winter, Bjorn Rotter, Sabina Havlíková, Boris Klempa, Theo P Schetters, Joppe W R Hovius
Affiliations

ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe

Hein Sprong et al. Parasit Vectors. .

Abstract

Ixodes ricinus transmits bacterial, protozoal and viral pathogens, causing disease and forming an increasing health concern in Europe. ANTIDotE is an European Commission funded consortium of seven institutes, which aims to identify and characterize tick proteins involved in feeding and pathogen transmission. The knowledge gained will be used to develop and evaluate anti-tick vaccines that may prevent multiple human tick-borne diseases. Strategies encompassing anti-tick vaccines to prevent transmission of pathogens to humans, animals or wildlife will be developed with relevant stakeholders with the ultimate aim of reducing the incidence of tick-borne diseases in humans.

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Figures

Figure 1
Figure 1
The participants of the official launch meeting of ANTIDotE. This meeting was held in Amsterdam, The Netherlands, in December 2013.
Figure 2
Figure 2
The ANTIDotE approach.Identification: Using state of the art proteomic and transcriptomic approaches we will identify novel tick salivary gland proteins. Characterization: These novel tick salivary gland proteins will be characterized using in silico, in vitro and in vivo techniques. Proof of concept: Promising candidates will be assessed in a proof of concept study as anti-tick vaccines to protect against tick-borne diseases. Both transmission as well as tick feeding parameters will be assessed. The symbols (from left to right) represent Babesia, Borrelia nd TBEV, respectively. Valorization plans: Through an integrated and multidisciplinary approach involving European public health institutes, health organizations and industrial companies, we will examine how to develop anti-tick vaccines and implement these in public health systems in Europe.
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