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Link to original content: https://pubmed.ncbi.nlm.nih.gov/24441197
HCN channels: new roles in sinoatrial node function - PubMed Skip to main page content
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Review
. 2014 Apr:15:83-90.
doi: 10.1016/j.coph.2013.12.005. Epub 2014 Jan 20.

HCN channels: new roles in sinoatrial node function

Christian Wahl-Schott  1 , Stefanie Fenske  2 , Martin Biel  3
Affiliations
Review

HCN channels: new roles in sinoatrial node function

Christian Wahl-Schott et al. Curr Opin Pharmacol. 2014 Apr.

Abstract

Hyperpolarization-activated cyclic nucleotide gated (HCN) channels pass a cationic current (Ih/If) that crucially contributes to the slow diastolic depolarization (SDD) of sinoatrial pacemaker cells and, hence, is a key determinant of cardiac automaticity and the generation of the heart beat. There is growing evidence, that HCN channel functions in the sinoatrial node (SAN) are not restricted to impulse formation but are also required for impulse propagation. In addition, HCN channels are involved in coordination and maintenance of sinoatrial network activity and, hence, are crucial for stabilizing cardiac rhythmicity. In the present review we will outline these new concepts.

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