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Link to original content: https://pubmed.ncbi.nlm.nih.gov/23413893/
Racial differences in CT phenotypes in COPD - PubMed Skip to main page content
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Clinical Trial
. 2013 Feb;10(1):20-7.
doi: 10.3109/15412555.2012.727921.

Racial differences in CT phenotypes in COPD

Nadia N Hansel  1 , George R Washko, Marilyn G Foreman, MeiLan K Han, Eric A Hoffman, Dawn L DeMeo, R Graham Barr, Edwin J R Van Beek, Ella A Kazerooni, Robert A Wise, Robert H Brown, Jennifer Black-Shinn, John E Hokanson, Nicola A Hanania, Barry Make, Edwin K Silverman, James D Crapo, Mark T Dransfield; COPDGene Investigators
Collaborators, Affiliations
Clinical Trial

Racial differences in CT phenotypes in COPD

Nadia N Hansel et al. COPD. 2013 Feb.

Abstract

Background: Whether African Americans (AA) are more susceptible to COPD than non-Hispanic Whites (NHW) and whether racial differences in disease phenotype exist is controversial. The objective is to determine racial differences in the extent of emphysema and airway remodeling in COPD.

Methods: First, 2,500 subjects enrolled in the COPDGene study were used to evaluate racial differences in quantitative CT (QCT) parameters of% emphysema, air trapping and airway wall thickness. Independent variables studied included race, age, gender, education, BMI, pack-years, smoking status, age at smoking initiation, asthma, previous work in dusty job, CT scanner and center of recruitment.

Results: Of the 1,063 subjects with GOLD Stage II-IV COPD, 200 self-reported as AA. AAs had a lower mean% emphysema (13.1% vs. 16.1%, p = 0.005) than NHW and proportionately less emphysema in the lower lung zones. After adjustment for covariates, there was no statistical difference by race in air trapping or airway wall thickness. Measured QCT parameters were more predictive of poor functional status in NHWs compared to AAs.

Conclusions: AAs have less emphysema than NHWs but the same degree of airway disease. Additional factors not easily assessed by current QCT techniques may account for the poor functional status in AAs.

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Conflict of interest statement

Declaration of Interest

Conflict of Interests: MKH has performed consulting for Nycomed and Novartis; participated on advisory boards for Novartis, Genentech, GlaxoSmithKline, Pfizer, Boehringer Ingelheim and MedImmune; and, participated on speaker bureaus for GlaxoSmithKline, Boehringer Ingelheim and Pfizer. BM has participated in advisory boards, speaker bureaus, consultations and multi-center clinical trials related to COPD with funding from the National Heart Lung and Blood Institute, Abbott, Astellas, AstraZeneca, Boerhinger-Ingelheim, Dey, Embryon, Forest, GlaxoSmithKline, NABI, NyComed, Novartis, Pfizer, Respironics, Schering, Sequal and Talecris. He has no direct conflicts with the topic of this manuscript. EKS received grant support and consulting fees from Glaxo- SmithKline for studies of COPD genetics; and received honoraria and consulting fees from AstraZeneca. All other authors – none. All authors are responsible for the content and writing of this paper.

Figures

Figure 1
Figure 1
Distribution of quantitative CT total percent emphysema by race.
Figure 2
Figure 2
Distribution of quantitative CT percent emphysema in the lower lung zones by race.
See this image and copyright information in PMC

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