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Review
. 2012 Oct 17;10(10):CD001321.
doi: 10.1002/14651858.CD001321.pub5.

Cranberries for preventing urinary tract infections

Ruth G Jepson  1 , Gabrielle Williams, Jonathan C Craig
Affiliations
Review

Cranberries for preventing urinary tract infections

Ruth G Jepson et al. Cochrane Database Syst Rev. .

Update in

Abstract

Background: Cranberries have been used widely for several decades for the prevention and treatment of urinary tract infections (UTIs). This is the third update of our review first published in 1998 and updated in 2004 and 2008.

Objectives: To assess the effectiveness of cranberry products in preventing UTIs in susceptible populations.

Search methods: We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL in The Cochrane Library) and the Internet. We contacted companies involved with the promotion and distribution of cranberry preparations and checked reference lists of review articles and relevant studies.Date of search: July 2012

Selection criteria: All randomised controlled trials (RCTs) or quasi-RCTs of cranberry products for the prevention of UTIs.

Data collection and analysis: Two authors independently assessed and extracted data. Information was collected on methods, participants, interventions and outcomes (incidence of symptomatic UTIs, positive culture results, side effects, adherence to therapy). Risk ratios (RR) were calculated where appropriate, otherwise a narrative synthesis was undertaken. Quality was assessed using the Cochrane risk of bias assessment tool.

Main results: This updated review includes a total of 24 studies (six cross-over studies, 11 parallel group studies with two arms; five with three arms, and two studies with a factorial design) with a total of 4473 participants. Ten studies were included in the 2008 update, and 14 studies have been added to this update. Thirteen studies (2380 participants) evaluated only cranberry juice/concentrate; nine studies (1032 participants) evaluated only cranberry tablets/capsules; one study compared cranberry juice and tablets; and one study compared cranberry capsules and tablets. The comparison/control arms were placebo, no treatment, water, methenamine hippurate, antibiotics, or lactobacillus. Eleven studies were not included in the meta-analyses because either the design was a cross-over study and data were not reported separately for the first phase, or there was a lack of relevant data. Data included in the meta-analyses showed that, compared with placebo, water or not treatment, cranberry products did not significantly reduce the occurrence of symptomatic UTI overall (RR 0.86, 95% CI 0.71 to 1.04) or for any the subgroups: women with recurrent UTIs (RR 0.74, 95% CI 0.42 to 1.31); older people (RR 0.75, 95% CI 0.39 to 1.44); pregnant women (RR 1.04, 95% CI 0.97 to 1.17); children with recurrent UTI (RR 0.48, 95% CI 0.19 to 1.22); cancer patients (RR 1.15 95% CI 0.75 to 1.77); or people with neuropathic bladder or spinal injury (RR 0.95, 95% CI: 0.75 to 1.20). Overall heterogeneity was moderate (I² = 55%). The effectiveness of cranberry was not significantly different to antibiotics for women (RR 1.31, 95% CI 0.85, 2.02) and children (RR 0.69 95% CI 0.32 to 1.51). There was no significant difference between gastrointestinal adverse effects from cranberry product compared to those of placebo/no treatment (RR 0.83, 95% CI 0.31 to 2.27). Many studies reported low compliance and high withdrawal/dropout problems which they attributed to palatability/acceptability of the products, primarily the cranberry juice. Most studies of other cranberry products (tablets and capsules) did not report how much of the 'active' ingredient the product contained, and therefore the products may not have had enough potency to be effective.

Authors' conclusions: Prior to the current update it appeared there was some evidence that cranberry juice may decrease the number of symptomatic UTIs over a 12 month period, particularly for women with recurrent UTIs. The addition of 14 further studies suggests that cranberry juice is less effective than previously indicated. Although some of small studies demonstrated a small benefit for women with recurrent UTIs, there were no statistically significant differences when the results of a much larger study were included. Cranberry products were not significantly different to antibiotics for preventing UTIs in three small studies. Given the large number of dropouts/withdrawals from studies (mainly attributed to the acceptability of consuming cranberry products particularly juice, over long periods), and the evidence that the benefit for preventing UTI is small, cranberry juice cannot currently be recommended for the prevention of UTIs. Other preparations (such as powders) need to be quantified using standardised methods to ensure the potency, and contain enough of the 'active' ingredient, before being evaluated in clinical studies or recommended for use.

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Conflict of interest statement

None known

Figures

1
1
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
1.1
1.1. Analysis
Comparison 1 Cranberry products versus placebo/control, Outcome 1 Participants with one or more UTIs at follow‐up.
1.2
1.2. Analysis
Comparison 1 Cranberry products versus placebo/control, Outcome 2 Adverse effects.
2.1
2.1. Analysis
Comparison 2 Cranberry products versus antibiotics, Outcome 1 Repeat symptomatic UTI.
2.2
2.2. Analysis
Comparison 2 Cranberry products versus antibiotics, Outcome 2 Adverse effects.
3.1
3.1. Analysis
Comparison 3 Cranberry dose: 2 or more/day versus 1 dose/day, Outcome 1 Symptomatic UTI.
3.2
3.2. Analysis
Comparison 3 Cranberry dose: 2 or more/day versus 1 dose/day, Outcome 2 Adverse effects.
4.1
4.1. Analysis
Comparison 4 Cranberry (dose: ≥ 2/day) versus placebo, Outcome 1 Symptomatic UTI.
4.2
4.2. Analysis
Comparison 4 Cranberry (dose: ≥ 2/day) versus placebo, Outcome 2 Adverse effects.
5.1
5.1. Analysis
Comparison 5 Cranberry products versus methenamine hippurate, Outcome 1 Symptomatic UTI.
6.1
6.1. Analysis
Comparison 6 Cranberry versus probiotics, Outcome 1 Symptomatic UTI.
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References

References to studies included in this review

Avorn 1994 {published data only}
    1. Avorn J, Monane M, Gurwitz J, Glynn R. Reduction of bacteriuria and pyuria with cranberry beverage: a randomized trial [abstract]. Journal of the American Geriatrics Society 1993;41(10 Suppl):SA13.
    1. Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA 1994;271(10):751‐4. [MEDLINE: ] - PubMed
Barbosa‐Cesnik 2011 {published data only}
    1. Barbosa‐Cesnik C, Brown MB, Buxton M, Zhang L, DeBusscher J, Foxman B. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo‐controlled trial. Clinical Infectious Diseases 2011;52(1):23‐30. [MEDLINE: ] - PMC - PubMed
    1. Eells SJ, McKinnell JA, Miller LG. Daily cranberry prophylaxis to prevent recurrent urinary tract infections may be beneficial in some populations of women . Clinical Infectious Diseases 2011 Jun;52(11):1393‐4. [MEDLINE: ] - PMC - PubMed
Cowan 2012 {published data only}
    1. Cowan CC, Hutchison C, Cole T, Barry SJ, Paul J, Reed NS, et al. A randomised double‐blind placebo controlled trial to determine the effect of cranberry juice on decreasing the incidence of urinary symptoms and urinary tract infections in patients undergoing radiotherapy for cancer of the bladder or cervix. Clinical Oncology 2012;24(2):e31‐8. [MEDLINE: ] - PubMed
Essadi 2010 {published data only}
    1. Essadi F, Elmehashi MO. Efficacy of cranberry juice for the prevention of urinary tract infections in pregnancy [abstract]. Journal of Maternal‐Fetal & Neonatal Medicine 2010;23:378. [EMBASE: 70200859]
Ferrara 2009 {published data only}
    1. Ferrara P, Romaniello L, Vitelli O, Gatto A, Serva M, Cataldi L. Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children. Scandinavian Journal of Urology & Nephrology 2009;43(5):369‐72. [MEDLINE: ] - PubMed
Foda 1995 {published data only}
    1. Foda MM, Middlebrook PF, Gatfield CT, Potvin G, Wells G, Schillinger JF. Efficacy of cranberry in prevention of urinary tract infection in a susceptible pediatric population. Canadian Journal of Urology 1995;2(1):98‐102. [CENTRAL: CN‐00433652] - PubMed
Haverkorn 1994 {published data only}
    1. Haverkorn MJ, Mandigers J. Reduction of bacteriuria and pyuria using cranberry juice. JAMA 1994;272(8):590. [MEDLINE: ] - PubMed
Hess 2008 {published data only}
    1. Hess MJ, Hess, PR, Sullivan MR, Nee M, Yalla SV. Evaluation of cranberry tablets for the prevention of urinary tract infections in spinal cord injured patients with neurogenic bladder. Spinal Cord 2008;46(9):622‐6. [MEDLINE: ] - PubMed
Kontiokari 2001 {published data only}
    1. Kontiokari T, Sundqvist K, Nuutinen M, Pokka T, Koskela M, Uhari M. Randomised trial of cranberry‐lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ 2001;322(7302):1571‐3. [MEDLINE: ] - PMC - PubMed
Lee 2007 {published data only}
    1. Lee BB, Haran MJ, Hunt LM, Simpson JM, Marial O, Rutkowski SB, et al. Spinal‐injured neuropathic bladder antisepsis (SINBA) trial. Spinal Cord 2007;45(8):542‐50. [MEDLINE: ] - PubMed
Linsenmeyer 2004 {published data only}
    1. Linsenmeyer TA, Harrison B, Oakley A, Kirshblum S, Stock JA, Millis SR. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospective, double‐blinded, placebo‐controlled, crossover study. Journal of Spinal Cord Medicine 2004;27(1):29‐34. [MEDLINE: ] - PubMed
McGuiness 2002 {published data only (unpublished sought but not used)}
    1. McGuiness SD, Krone R, Metz LM. A double‐blind, randomized, placebo‐controlled trial of cranberry supplements in multiple sclerosis. Journal of Neuroscience Nursing 2002;34(1):4‐7.
McMurdo 2005 {published data only}
    1. McMurdo ME, Bissett LY, Price RJ, Phillips G, Crombie IK. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double‐blind, placebo‐controlled trial. Age & Ageing 2005;34(3):256‐61. [MEDLINE: ] - PubMed
McMurdo 2009 {published data only}
    1. McMurdo ME, Argo I, Phillips G, Daly F, Davey P. Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women. Journal of Antimicrobial Chemotherapy 2009;63(2):389‐95. [MEDLINE: ] - PMC - PubMed
NAPRUTI Study 2011 I {published data only}
    1. Beerepoot MA, Stobberingh EE, Geerlings SE. A study of non‐antibiotic versus antibiotic prophylaxis for recurrent urinary‐tract infections in women (the NAPRUTI study) [Onderzoek naar niet‐antibiotische versus antibiotische profylaxe bij vrouwen met recidiverende urineweginfecties (de NAPRUTI‐studie)]. Nederlands Tijdschrift voor Geneeskunde 2006;150(10):574‐5. [MEDLINE: ] - PubMed
    1. Beerepoot MA, Ter Riet G, Nys S, Wal WM, Borgie CA, Reijke TM, et al. Cranberries vs antibiotics to prevent urinary tract infections: a randomized double‐blind noninferiority trial in premenopausal women. Archives of Internal Medicine 2011;171(14):1270‐8. [MEDLINE: ] - PubMed
    1. Gurley BJ. Cranberries as antibiotics?: Comment on "Cranberries vs antibiotics to prevent urinary tract infections: a randomized double‐blind noninferiority trial in premenopausal women" . Archives of Internal Medicine 2011 Jul 25;171(14):1279‐80. [MEDLINE: ] - PubMed
PACS Study 2008 {published and unpublished data}
    1. Juthani‐Mehta M, Perley L, Chen S, Dziura J, Gupta K. Feasibility of cranberry capsule administration and clean‐catch urine collection in long‐term care residents . Journal of the American Geriatrics Society 2010 Oct;58(10):2028‐30. [MEDLINE: ] - PMC - PubMed
Salo 2010 {published and unpublished data}
    1. Salo J, Kontiokari T, Helminen M, Korppi M, Nieminen T, Pokka T, et al. Randomized trial of cranberry juice for the prevention of recurrences of urinary tract infections in children [abstract]. Clinical Microbiology & Infection 2010;16(Suppl 2):S385‐6. [EMBASE: 70195963] - PubMed
    1. Salo J, Uhari M, Helminen M, Korppi M, Nieminen T, Pokka T, et al. Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo‐controlled trial. Clinical Infectious Diseases 2011;54(3):340‐6. [MEDLINE: ] - PubMed
Schlager 1999 {published data only}
    1. Schlager TA, Anderson S, Trudell J, Hendley JO. Effect of cranberry juice on bacteriuria in children with neurogenic bladder receiving intermittent catheterization. Journal of Pediatrics 1999;135(6):698‐702. [MEDLINE: ] - PubMed
Sengupta 2011 {published data only}
    1. Sengupta K, Alluri KV, Golakoti T, Gottumukkala GV, Raavi J, Kotchrlakota L, et al. A randomized, double blind, controlled, dose dependent clinical trial to evaluate the efficacy of a proanthocyanidin standardized whole cranberry (Vaccinium macrocarpon) powder on infections of the urinary tract. Current Bioactive Compounds 2011;7(1):39‐46. [EMBASE: 2011201647]
Stothers 2002 {published data only}
    1. Stothers L. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Canadian Journal of Urology 2002;9(3):1558‐62. [MEDLINE: ] - PubMed
Uberos 2010 {published data only}
    1. Uberos J, Nogueras‐Ocana M, Fernandez‐Puentes V, Rodriguez‐Belmonte R, Narbona‐López E, Molina‐Carballo A, et al. Cranberry syrup vs trimethoprim in the prophylaxis of recurrent urinary tract infections among children: a controlled trial. Open Access Journal of Clinical Trials 2012;4:31–8. [EMBASE: 2012351759]
    1. Uberos J, Rodrguez‐Belmonte R, Fernndez‐Puentes V, Narbona‐Lpez E, Molina‐Carballo A, Munoz‐Hoyos A. Cranberry syrup vs. trimethoprim in the prophylaxis of recurrent urinary infection: A double‐blind randomized clinical trial [abstract]. Acta Paediatrica 2010;99(Suppl 462):48. [EMBASE: 70313001]
Waites 2004 {published data only}
    1. Waites KB, Canupp KC, Armstrong S, DeVivo MJ. Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injury. Journal of Spinal Cord Medicine 2004;27(1):35‐40. [MEDLINE: ] - PubMed
Walker 1997 {published data only}
    1. Walker EB, Barney DP, Mickelsen JN, Walton RJ, Mickelsen RA Jr. Cranberry concentrate: UTI prophylaxis. Journal of Family Practice 1997;45(2):167‐8. [MEDLINE: ] - PubMed
Wing 2008 {published data only}
    1. Wing DA, Rumney PJ, Leu SY, Zaldivar F. Comparison of urinary cytokines after ingestion of cranberry juice cocktail in pregnant subjects: a pilot study. American Journal of Perinatology 2010;27(2):137‐42. [MEDLINE: ] - PubMed
    1. Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. Journal of Urology 2008;180(4):1367‐72. [MEDLINE: ] - PMC - PubMed

References to studies excluded from this review

Howell 2010 {published data only}
    1. Howell AB, Botto H, Combescure C, Blanc‐Potard AB, Gausa L, Matsumoto T, et al. Dosage effect on uropathogenic Escherichia coli anti‐adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infectious Diseases 2010;10:94. [MEDLINE: ] - PMC - PubMed
Jackson 1997 {published data only}
    1. Jackson B, Hicks LE. Effect of cranberry juice on urinary pH in older adults. Home Healthcare Nurse 1997;15(3):199‐202. [MEDLINE: ] - PubMed
Jass 2009 {published data only}
    1. Jass J, Reid G. Effect of cranberry drink on bacterial adhesion in vitro and vaginal microbiota in healthy females. Canadian Journal of Urology 2009;16(6):4901‐7. [MEDLINE: ] - PubMed
Lavigne 2008 {published data only}
    1. Lavigne JP, Bourg G, Combescure C, Botto H, Sotto A. In‐vitro and in‐vivo evidence of dose‐dependent decrease of uropathogenic Escherichia coli virulence after consumption of commercial Vaccinium macrocarpon (cranberry) capsules. Clinical Microbiology & Infection 2008;14(4):350‐5. [MEDLINE: ] - PMC - PubMed
Schultz 1984 {published data only}
    1. Schultz A. Efficacy of cranberry juice and ascorbic acid in acidifying the urine in multiple sclerosis subjects. Journal of Community Health Nursing 1984;1(3):159‐69. [MEDLINE: ] - PubMed
Tempera 2010 {published data only}
    1. Tempera G, Corsello S, Genovese C, Caruso FE, Nicolosi D. Inhibitory activity of cranberry extract on the bacterial adhesiveness in the urine of women: an ex‐vivo study. International Journal of Immunopathology & Pharmacology 2010;23(2):611‐8. [MEDLINE: ] - PubMed
Valentova 2007 {published data only}
    1. Valentova K, Stejskal D, Bednar P, Vostalova J, Cihalik C, Vecerova R, et al. Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double‐blind placebo‐controlled trial. Journal of Agricultural & Food Chemistry 2007;55(8):3217‐24. [MEDLINE: ] - PubMed
Vidlar 2010 {published data only}
    1. Vidlar A, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, et al. The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms. British Journal of Nutrition 2010;104(8):1181‐9. [MEDLINE: ] - PubMed

References to studies awaiting assessment

Afshar 2012 {published data only}
    1. Afshar K, Stothers L, Scott H, MacNeily AE. Cranberry juice for the prevention of pediatric urinary tract infection: a randomized controlled trial. Journal of Urology 2012;188(4 Suppl):1584‐7. [MEDLINE: ] - PubMed
Bonetta 2011 {published data only}
    1. Bonetta A, Derelli R, Pierro F. Cranberry extracts reduce urinary tract infections during radiotherapy for prostate adenocarcinoma [abstract]. Anticancer Research 2011;31(5):1849‐50. [EMBASE: 70437696]
NCT01079169 {published data only}
    1. NCT01079169. Evaluation of the effect of cranberry capsules on the occurrence of urinary tract infections during post‐acute rehabilitation of spinal cord injured patients. www.clinicaltrials.gov/ct2/show/NCT01079169 (accessed 4 June 2013).
Stapleton 2012 {published data only (unpublished sought but not used)}
    1. Stapleton AE, Dziura J, Hooton TM, Cox ME, Yarova‐Yarovaya Y, Chen S, et al. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial . Mayo Clinic Proceedings 2012;87(2):143‐50. [MEDLINE: ] - PMC - PubMed

References to ongoing studies

NCT00100061 {unpublished data only}
    1. NCT00100061. Dose response to cranberry of women with recurrent UTIs. clinicaltrials.gov/ct2/show/NCT00100061 (accessed 11 September 2012).
NCT00280592 {unpublished data only}
    1. NCT00280592. Prospective, randomized, double‐blind, placebo‐controlled study on parallel groups evaluating the efficacy and safety of cranberry (Vaccinium Macrocarpon) in prevention of urinary tract infections in multiple sclerosis patients. clinicaltrials.gov/ct2/show/NCT00280592 (accessed 11 September 2012).
NCT01033383 {unpublished data only}
    1. NCT01033383. Pilot study: Dosing study of cranberry capsules for the prevention of bacteriuria in nursing home residents. clinicaltrials.gov/ct2/show/NCT01033383 (accessed 11 September 2012).

Additional references

Epp 2010
    1. Epp A, Larochelle A, Lovatsis D, Walter JE, Easton W, Farrell SA, et al. Recurrent urinary tract infection. Journal of Obstetrics & Gynaecology Canada: JOGC 2010;32(11):1082–101. [MEDLINE: ] - PubMed
Foo 2000
    1. Foo LY, Lu Y, Howell AB, Vorsa N. The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P‐fimbriated Escherichia coli in vitro. Phytochemistry 2000;54(2):173‐81. [MEDLINE: ] - PubMed
Foxman 2000
    1. Foxman B, Gillespie B, Koopman J, Zhang L, Palin K, Tallman P, et al. Risk factors for second urinary tract infection among college women.. American Journal of Epidemiology 2000;151(12):1194–205. - PubMed
Foxman 2002
    1. Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. American Journal of Medicine 2002;113 Suppl 1A:5S‐13S. [MEDLINE: ] - PubMed
Giesen 2010
    1. Giesen L, Cousins G, Dimitrov B, Laar F, Fahey T. Predicting acute uncomplicated urinary tract infection in women: a systematic review of the diagnostic accuracy of symptoms and signs. BMC Family Practice 2010;11:78. [MEDLINE: ] - PMC - PubMed
Hellstrom 1991
    1. Hellstrom A, Hanson E, Hansson S, Hjalmas K, Jodal U. Association between urinary symptoms at 7 years old and previous urinary tract infection. Archives of Disease in Childhood 1991;66(2):232‐4. [MEDLINE: ] - PMC - PubMed
Hopkins 1994
    1. Hopkins WJ, Heisley DM, Jonler M, Uehling DT. Reduction of bacteriuria and pyuria using cranberry juice. JAMA 1994;272(8):588‐9. [MEDLINE: ] - PubMed
Howell 2002
    1. Howell AB, Foxman B. Cranberry juice and adhesion of antibiotic‐resistant uropathogens. JAMA 2002;287(23):3082‐3. [MEDLINE: ] - PubMed
Howell 2005
    1. Howell AB, Reed JD, Kreuger CG, Winterbottom R, Cunningham DG, Leahy M. A‐type cranberry proanthocyanidins and uropathogenic bacterial anti‐adhesion activity. Phytochemistry 2005;66(18):2281‐91. [MEDLINE: ] - PubMed
Howell 2007
    1. Howell AB. Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Molecular Nutrition & Food Research 2007;51(6):732‐7. [MEDLINE: ] - PubMed
Kahn 1967
    1. Kahn HD, Panariello VA, Saeli J, Sampson JR, Schwartz E. Effect of cranberry juice on urine. Journal of the American Dietetic Association 1967;51(3):251‐4. [MEDLINE: ] - PubMed
Katz 1994
    1. Katz LM. Reduction of bacteriuria and pyuria using cranberry juice. JAMA 1994;272(8):589. [MEDLINE: ] - PubMed
Kelly 1977
    1. Kelly J. Clinical syndromes of urinary tract infection. Current Therapeutics 1977;38(7):15‐21.
Kinney 1979
    1. Kinney AB, Blount M. Effect of cranberry juice on urinary pH. Nursing Research 1979;28(5):287‐90. [MEDLINE: ] - PubMed
McLeod 1978
    1. McLeod DC, Nahata MC. Methenamine therapy and urine acidification with ascorbic acid and cranberry juice. American Journal of Hospital Pharmacy 1978;35(6):654. [MEDLINE: ] - PubMed
Patton 1991
    1. Patton JP, Nash DB, Abrutyn E. Urinary tract infection: economic considerations. Medical Clinics of North America 1991;75(2):495‐513. [MEDLINE: ] - PubMed
Prior 2010
    1. Prior RL, Fan E, Hongping J, Howell A, Nio C, Payne M, et al. Multi‐laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders. Journal of the Science of Food & Agriculture 2010;90(9):1473‐8. [MEDLINE: ] - PubMed
Roberts 1979
    1. Roberts AP, Phillips R. Bacteria causing symptomatic urinary tract infection or asymptomatic bacteriuria. Journal of Clinical Pathology 1979;32(5):492‐6. [MEDLINE: ] - PMC - PubMed
Schmidt 1988
    1. Schmidt DR, Sobota AE. An examination of the anti‐adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios 1988;55(224‐255):173‐81. [MEDLINE: ] - PubMed
Stapleton 1997
    1. Stapleton A, Stamm WE. Prevention of urinary tract infection. Infectious Disease Clinics of North America 1997;11(3):719‐33. [MEDLINE: ] - PubMed
Wang 2012
    1. Wang CH, Fang CC, Chen NC, Liu SS, Yu PH, Wu TY, et al. Cranberry‐containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta‐analysis of randomized controlled trials.. Archives of Internal Medicine 2012;172(13):988‐96. [MEDLINE: ] - PubMed
Winberg 1974
    1. Winberg J, Andersen HJ, Bergstrom T, Jacobsson B, Larson H, Lincoln K. Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatrica Scandinavica ‐ Supplement 1974, (252):1‐20. [MEDLINE: ] - PubMed
Wong 1984
    1. Wong ES, Fennell Cl, Stamm WE. Urinary tract infection among women attending a clinic for sexually transmitted diseases. Sexually Transmitted Diseases 1984;11(1):18‐23. [MEDLINE: ] - PubMed
Zafriri 1989
    1. Zafriri D, Ofek I, Adar R, Pocino M, Sharon N. Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells. Antimicrobial Agents & Chemotherapy 1989;33(1):92‐8. [MEDLINE: ] - PMC - PubMed

References to other published versions of this review

Jepson 1998a
    1. Jepson RG, Mihaljevic L, Craig J. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews 1998, Issue 2. - PubMed
Jepson 1998b
    1. Jepson RG, Mihaljevic L, Craig JC. Cranberries for treating urinary tract infections. Cochrane Database of Systematic Reviews 1998, Issue 4. [DOI: 10.1002/14651858.CD001322] - DOI - PMC - PubMed
Jepson 2004a
    1. Jepson RG, Mihaljevic L, Craig J. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews 2004, Issue 1. [DOI: 10.1002/14651858.CD001321.pub2] - DOI - PubMed
Jepson 2004b
    1. Jepson RG, Mihaljevic L, Craig J. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews 2004, Issue 2. [DOI: 10.1002/14651858.CD001321.pub3] - DOI - PubMed
Jepson 2008
    1. Jepson RG, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews 2008, Issue 1. [DOI: 10.1002/14651858.CD001321.pub4] - DOI - PubMed