iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://pubmed.ncbi.nlm.nih.gov/22431797/
Clinical definitions of pertussis: Summary of a Global Pertussis Initiative roundtable meeting, February 2011 - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jun;54(12):1756-64.
doi: 10.1093/cid/cis302. Epub 2012 Mar 19.

Clinical definitions of pertussis: Summary of a Global Pertussis Initiative roundtable meeting, February 2011

James D Cherry  1 , Tina Tan, Carl-Heinz Wirsing von König, Kevin D Forsyth, Usa Thisyakorn, David Greenberg, David Johnson, Colin Marchant, Stanley Plotkin
Affiliations

Clinical definitions of pertussis: Summary of a Global Pertussis Initiative roundtable meeting, February 2011

James D Cherry et al. Clin Infect Dis. 2012 Jun.

Abstract

Existing clinical case definitions of pertussis are decades old and based largely on clinical presentation in infants and children, yet an increasing burden is borne by adolescents and adults who may manifest distinct signs/symptoms. Therefore, a "one-size-fits-all" clinical case definition is no longer appropriate. Seeking to improve pertussis diagnosis, the Global Pertussis Initiative (GPI) developed an algorithm that delineates the signs/symptoms of pertussis most common to 3 age groups: 0-3 months, 4 months to 9 years, and ≥10 years. These case definitions are based on clinical presentation alone, but do include recommendations on laboratory diagnostics. Until pertussis can be accurately diagnosed, its burden will remain underestimated, making the introduction of epidemiologically appropriate preventive strategies difficult. The proposed definitions are intended to be widely applicable and to encourage the expanded use of laboratory diagnostics. Determination of their utility and their sensitivity and/or specificity versus existing case definitions is required.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Algorithm for the diagnosis of pertussis. Abbreviations: IgG, immunoglobin G; PCR, polymerase chain reaction; PT, pertussis toxin; RSV, respiratory syncytial virus; WBC, white blood cell. aIn resource-limited areas where PCR is not available, samples may be sent to a reference laboratory for culture confirmation. bFalse-negatives possible. cSerology not useful in this age cohort.
Figure 2.
Figure 2.
Clinical case definition of pertussis for surveillance purposes.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cherry JD, Grimprel E, Guiso N, et al. Defining pertussis epidemiology. Pediatr Infect Dis J. 2005;24(5 suppl):S25–4. - PubMed
    1. World Health Organization Department of Vaccines and Biologicals. Pertussis Surveillance: A Global Meeting. WH/V&B/01.19. Geneva: World Health Organization; 2001.
    1. Centers for Disease Control and Prevention (CDC) Appendix B. CDC and Council of State and Territorial Epidemiologists (CSTE) pertussis case definition. MMWR Recomm Rep. 2006;55(RR03):36. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5503a3.htm. Accessed 20 September 2011.
    1. Guiso N, Wirsing von König CH, Forsyth K, Tan T, Plotkin SA. The Global Pertussis Initiative: report from a round table meeting to discuss the epidemiology and detection of pertussis, Paris, France, 11–12 January 2010. Vaccine. 2011;29:1115–21. - PubMed
    1. EU case definition Pertussis: Commission Decision of 28 April 2008 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No. 2119/98/EC of the European Parliament and of the Council, Official Journal of the European Union. Available at: http://eurlex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2008:159:0046:.... Accessed 20 September 2011.

Publication types