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Review
. 2012:6:1-11.
doi: 10.2147/DDDT.S12894. Epub 2011 Dec 22.

Treatment for primary hypothyroidism: current approaches and future possibilities

Ali J Chakera  1 , Simon H S Pearce, Bijay Vaidya
Affiliations
Review

Treatment for primary hypothyroidism: current approaches and future possibilities

Ali J Chakera et al. Drug Des Devel Ther. 2012.

Abstract

Primary hypothyroidism is the most common endocrine disease. Although the diagnosis and treatment of hypothyroidism is often considered simple, there are large numbers of people with this condition who are suboptimally treated. Even in those people with hypothyroidism who are biochemically euthyroid on levothyroxine replacement there is a significant proportion who report poorer quality of life. This review explores the historical and current treatment options for hypothyroidism, reasons for and potential solutions to suboptimal treatment, and future possibilities in the treatment of hypothyroidism.

Keywords: levothyroxine; primary hypothyroidism; thyroid; thyroid-stimulating hormone; triiodothyronine.

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Figures

Figure 1
Figure 1
Algorithm for the pragmatic management of primary hypothyroidism. Note: Reproduced from British Medical Journal, Vaidya B, Pearce SH, 337, 284–289, 2008 with permission from BMJ Publishing Group Ltd. Abbreviations: TSH, thyroid stimulating hormone; FT4, free thyroxine; TPO, thyroid peroxidase; mIU, milli-international unit.
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