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Link to original content: https://pubmed.ncbi.nlm.nih.gov/22098224/
Bioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials - PubMed Skip to main page content
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Clinical Trial
. 2013;65(6):919-29.
doi: 10.1080/01635581.2011.630156. Epub 2011 Nov 18.

Bioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials

Torsten Bohn  1 , Michelle Blackwood, David Francis, Qingguo Tian, Steven J Schwartz, Steven K Clinton
Affiliations
Clinical Trial

Bioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials

Torsten Bohn et al. Nutr Cancer. 2013.

Abstract

Studies suggest that tomato and soy foods may contribute to a lower risk of certain cancers. We developed a novel soy germ tomato juice to be used in controlled cancer prevention trials. This study describes an initial test of compliance, phytochemical bioavailability, and effects on biomarkers of blood lipids. Healthy men and women (n = 18) consumed a soy germ-fortified juice daily (300 mL supplying 66 mg isoflavones and 22 mg lycopene) for 8 wk. A single-dose bioavailability study was completed on day 1 and isoflavones in plasma and urine, and lycopene in the plasma, were measured. All subjects completed the trial, with 97.7% ± 3.5% (mean ± SD) of the scheduled juice consumed. No adverse effects were documented. The postprandial study indicated that 3.1% ± 2.3% of lycopene was absorbed and that 49.3% ± 12.1% isoflavones ingested were recovered in 24-h urines. Lycopene plasma concentration changed from 0.60 ± 0.22 to 1.24 ± 0.30 μmol/L during 8 wk of consumption. Juice consumption significantly improved resistance of LDL+VLDL-C to Cu(2+)-mediated oxidation (P = 0.039), HDL-C (47.3 ± 15.8 to 51.7 ± 14.8 mg/dL, P < 0.001), and the ratio of total-C/HDL-C (4.25 ± 1.59 to 3.63 ± 1.16, P < 0.001) at 8 wk. A well-characterized soy-fortified tomato juice can be produced in large scale for multiinstitutional long-term cancer prevention trials and showed excellent compliance with no toxicity, while demonstrating absorption of biologically active phytochemicals.

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Figures

FIG. 1
FIG. 1
Plasma appearance curves for daidzein, genistein, glycitein, dihydrodaidzein (DHD), dihydrogenistein (DHG), and O-desmethylangolensin (O-DMA) after consuming 255 mL soy-fortified tomato juice containing 210.2 ± 12.4 μmol isoflavones at breakfast (8 a.m.), followed by a standardized lunch (12:30 p.m.). Error bars represent SD (n = 18).
FIG. 2
FIG. 2
Appearance of lycopene in plasma-TRL fractions after consumption of 255 mL soy-fortified tomato juice containing 34.6 ± 2.1 μmol lycopene at breakfast (8 a.m.), followed by a standardized lunch (12:30 p.m.). Error bars represent SD.
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