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Link to original content: https://pubmed.ncbi.nlm.nih.gov/2122258/
The GTPase superfamily: a conserved switch for diverse cell functions - PubMed Skip to main page content
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Review
. 1990 Nov 8;348(6297):125-32.
doi: 10.1038/348125a0.

The GTPase superfamily: a conserved switch for diverse cell functions

H R Bourne  1 , D A Sanders, F McCormick
Affiliations
Review

The GTPase superfamily: a conserved switch for diverse cell functions

H R Bourne et al. Nature. .

Abstract

Proteins that bind and hydrolyse GTP are being discovered at a rapidly increasing rate. Each of these many GTPases acts as a molecular switch whose 'on' and 'off' states are triggered by binding and hydrolysis of GTP. Conserved structure and mechanism in myriad versions of the switch--in bacteria, yeast, flies and vertebrates--suggest that all derive from a single primordial protein, repeatedly modified in the course of evolution to perform a dazzling variety of functions.

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