iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://pubmed.ncbi.nlm.nih.gov/2087873/
Mycobacterium vaccae in immunoprophylaxis and immunotherapy of leprosy and tuberculosis - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1990 Dec;8(6):525-30.
doi: 10.1016/0264-410x(90)90002-4.

Mycobacterium vaccae in immunoprophylaxis and immunotherapy of leprosy and tuberculosis

J L Stanford  1 , G A Rook, G M Bahr, Y Dowlati, R Ganapati, K Ghazi Saidi, S Lucas, G Ramu, P Torres, H Minh Ly, et al.
Affiliations
Review

Mycobacterium vaccae in immunoprophylaxis and immunotherapy of leprosy and tuberculosis

J L Stanford et al. Vaccine. 1990 Dec.

Abstract

Both leprosy and tuberculosis present continuing problems in their control, especially in the developing world, despite the availability of drugs effective in producing a bacteriological cure. Improved immunoprophylaxis, and an effective immunotherapy to be used with chemotherapy are urgently required. Intradermal injection of a suspension of killed Mycobacterium vaccae promotes cell-mediated responses to antigens common to all mycobacteria, and switches off the tissue-necrotizing aspects of the Koch phenomenon. These properties led to the use of the suspensions as an improved vaccine, either alone or in combination with BCG. The same properties led to the employment of the suspension in immunotherapy as an adjunct to chemotherapy in the treatment of both leprosy and tuberculosis. The evidence leading to these conclusions is reviewed and discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Substances

LinkOut - more resources