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Link to original content: https://pubmed.ncbi.nlm.nih.gov/20375889
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Review
. 2010 May;17(3):225-9.
doi: 10.1097/MOH.0b013e3283386638.

Vascular permeability to plasma, plasma proteins, and cells: an update

Harold F Dvorak  1
Affiliations
Review

Vascular permeability to plasma, plasma proteins, and cells: an update

Harold F Dvorak. Curr Opin Hematol. 2010 May.

Abstract

Purpose of review: The blood vasculature supplies tissues with nutrients, clears waste products, and carries and directs leukocytes to inflammatory sites. To accomplish these functions, microvessels regulate the extravasation of small molecules, plasma proteins and inflammatory cells. The mechanisms responsible for these events have been the subject of intense investigation and, often, dispute.

Recent findings: Recent progress has contributed to a better understanding of the mechanisms by which microvessels of different types and in different vascular beds regulate the passage of small and large molecules and cells. Roles are shown for the glycocalyx, caveolae, perictyes, sphingosine-1-phosphate, and newly discovered signaling pathways.

Summary: Vascular permeability is important for maintaining homeostasis and is greatly increased in acute and chronic inflammation, wound healing, and growing tumors. New work has contributed importantly to the mechanisms responsible for regulating permeability.

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References

    1. Nagy JA, Benjamin L, Zeng H, et al. Vascular permeability, vascular hyperpermeability and angiogenesis. Angiogenesis. 2008;11:109–119. - PMC - PubMed
    1. Nagy JA, Dvorak HF, Dvorak AM. VEGF-A and the induction of pathological angiogenesis. Annu Rev Pathol Mech Dis. 2007;2:251–275. - PubMed

    1. Salmon AH, Neal CR, Sage LM, et al. Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx. Cardiovasc Res. 2009;83:24–33.. This paper demonstrates that Ang-1, long known to be a vascular “stabilizer”, maintains normal BVP at lest in part by promoting glycocalyx synthesis.

    1. Chappell D, Hofmann-Kiefer K, Jacob M, et al. TNF-alpha induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin. Basic Res Cardiol. 2009;104:78–89.. An important implication of this paper is that EC receptors, e.g., ICAM and VCAM, are buried beneath the glycocalyx and are unable to react with cell-associated ligands until glycocalyx is degraded.

    1. Chappell D, Jacob M, Hofmann-Kiefer K, et al. Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion. Cardiovasc Res. 2009;83:388–396. - PubMed

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