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Link to original content: https://pubmed.ncbi.nlm.nih.gov/19878142
Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice - PubMed Skip to main page content
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. 2010 Jan;15(1):96-9.
doi: 10.1111/j.1369-1600.2009.00179.x.

Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

Tathiana A Alvarenga  1 , Monica L Andersen, Daniel A Ribeiro, Paula Araujo, Camila Hirotsu, José L Costa, Murilo C Battisti, Sergio Tufik
Affiliations

Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

Tathiana A Alvarenga et al. Addict Biol. 2010 Jan.

Abstract

We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins.

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