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Link to original content: https://pubmed.ncbi.nlm.nih.gov/19845638
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Review
. 2009 Oct:1178:186-93.
doi: 10.1111/j.1749-6632.2009.05004.x.

The fragmented gene

Jürgen Brosius  1
Affiliations
Review

The fragmented gene

Jürgen Brosius. Ann N Y Acad Sci. 2009 Oct.

Abstract

While once almost synonymous, there is an increasing gap between the expanding definition of what constitutes a gene and the conservative and narrowly defined terms code or coding, which for a long time, almost exclusively constituted the open reading frame. Much confusion results from this disparity, especially in light of the plethora of noncoding RNAs (more correctly termed "non-protein-coding RNAs") that usually are encoded and transcribed by their own genes. A simple solution would be to adopt Ed Trifonov's less constrained definition of a code as any sequence pattern that can have a biological function. Such consideration favors not only a more complex view of the gene as an entity composed of many more or less conserved subgenic modules, but also a concept of modular evolution of genes and entire genomes.

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