doi: 10.1111/j.1749-6632.2009.04729.x.
Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis
Affiliations
- PMID: 19723035
- DOI: 10.1111/j.1749-6632.2009.04729.x
Item in Clipboard
Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis
Ann N Y Acad Sci.
2009 Aug.
Abstract
A large complex of proteins, called CENPs, are associated with centromeric DNA. Some of them exhibit a cell cycle-related expression (e.g., CENP-E and -F) and are required for the transition from interphase to mitosis, whereas constitutive proteins (e.g., CENP-A, -B, -C, -G, and -H) reside permanently at the centromere and are essential for the correct kinetochore assembly. Poly(ADP-ribose) polymerase-1 (PARP-1), which plays an active role in many basic processes, was described as a possible regulator of CENPs. By multicolor immunofluorescence we therefore analyzed the distribution of PARP-1 and its interaction with CENP-B, -E, and -F during mitosis and apoptosis.
Similar articles
-
Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc.Hum Mol Genet. 2002 Sep 15;11(19):2319-29. doi: 10.1093/hmg/11.19.2319. Hum Mol Genet. 2002. PMID: 12217960
-
Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where?Exp Cell Res. 2001 Oct 1;269(2):193-201. doi: 10.1006/excr.2001.5293. Exp Cell Res. 2001. PMID: 11570811
-
Changes of mitochondria and relocation of the apoptosis-inducing factor during apoptosis.Ann N Y Acad Sci. 2009 Aug;1171:12-7. doi: 10.1111/j.1749-6632.2009.04707.x. Ann N Y Acad Sci. 2009. PMID: 19723032
-
Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.Chembiochem. 2008 Jan 4;9(1):77-92. doi: 10.1002/cbic.200700358. Chembiochem. 2008. PMID: 18072184
-
[Renal injury and apoptosis].Nihon Ika Daigaku Zasshi. 1997 Oct;64(5):475-8. doi: 10.1272/jnms1923.64.475. Nihon Ika Daigaku Zasshi. 1997. PMID: 9366155 Review. Japanese. No abstract available.
Cited by
-
Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.Cells. 2020 May 5;9(5):1135. doi: 10.3390/cells9051135. Cells. 2020. PMID: 32380691 Free PMC article.
-
Apoptosis regulation by subcellular relocation of caspases.Sci Rep. 2018 Aug 15;8(1):12199. doi: 10.1038/s41598-018-30652-x. Sci Rep. 2018. PMID: 30111833 Free PMC article.
-
Intracellular distribution of Tankyrases as detected by multicolor immunofluorescence techniques.Eur J Histochem. 2012 Jan 20;56(1):e4. doi: 10.4081/ejh.2012.e4. Eur J Histochem. 2012. PMID: 22472892 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
