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Link to original content: https://pubmed.ncbi.nlm.nih.gov/19394084
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. 2010 Nov;36(8):855-61.
doi: 10.1016/j.envint.2009.03.005. Epub 2009 Apr 24.

External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment

Karin Norström  1 , Gertje Czub, Michael S McLachlan, Dingfei Hu, Peter S Thorne, Keri C Hornbuckle
Affiliations

External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment

Karin Norström et al. Environ Int. 2010 Nov.

Abstract

Humans are exposed to different mixtures of PCBs depending on the route of exposure. In this study we investigated the potential contribution of inhalation to the overall human exposure to PCBs in an urban area. For this purpose, the mechanistically based, non-steady state bioaccumulation model ACC-HUMAN was applied to predict the PCB body burden in an adult living in the Midwestern United States who eats a typical North American diet and inhales air contaminated with PCBs. Dietary exposure was estimated using measured data for eighteen PCB congeners in different food groups (fish, meat and egg, dairy products). Two scenarios for inhalation exposure were evaluated: one using air concentrations measured in Chicago, and a second using air measurements in a remote area on Lake Michigan, Sleeping Bear Dunes. The model predicted that exposure via inhalation increases the accumulated mass of PCBs in the body by up to 30% for lower chlorinated congeners, while diet is by far the dominant source of exposure for those PCB congeners that accumulate most in humans.

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Figures

Figure 1
Figure 1
Ratio between measured and predicted lipid normalized concentrations of PCB congener in serum of 5 male residents of Chicago.
Figure 2
Figure 2
Predicted PCB concentrations in a 56 year old man exposed to PCBs via the diet and via inhalation of air from an urban (Chicago) and a remote area (Sleeping Bear Dunes). The dietary exposure was the same in both simulations and represented background exposure for this region. The concentrations of PCB 118 to PCB 201 have been divided by ten. l.w. = lipid weight.
Figure 3
Figure 3
Predicted PCB concentrations in a 56 year old man living in an urban environment divided by the corresponding concentrations for a person living in a remote environment.
Figure 4
Figure 4
Predicted PCB concentrations (ng/g l.w.) in a 56 year old man for whom the only source of exposure is inhalation of air from either an urban or remote environment. The concentrations of PCB 15 have been divided by ten. l.w. = lipid weight.
Figure 5
Figure 5
Predicted cumulative lifetime external exposure to PCBs via inhalation (56 year old man living in Chicago).
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