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Link to original content: https://pubmed.ncbi.nlm.nih.gov/17557195
Cell motility and cytoskeletal regulation in invasion and metastasis - PubMed Skip to main page content
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Review
. 2007 Sep;12(2-3):143-52.
doi: 10.1007/s10911-007-9046-4.

Cell motility and cytoskeletal regulation in invasion and metastasis

Dmitriy Kedrin  1 , Jacco van Rheenen, Lorena Hernandez, John Condeelis, Jeffrey E Segall
Affiliations
Review

Cell motility and cytoskeletal regulation in invasion and metastasis

Dmitriy Kedrin et al. J Mammary Gland Biol Neoplasia. 2007 Sep.

Abstract

Cell motility and chemotaxis can make important contributions to the metastatic cascade. Cell migration pathways in general play significant roles in a variety of physiological processes that can be "hijacked" by cancer cells. Both growth factors and chemokines provide important chemotactic signals in development and metastasis. Receptor activation, following binding of a growth factor or a chemokine, leads to dynamic morphological changes in the actin cytoskeleton network via a variety of distinct and interconnected pathways, resulting in translocation of the cell up a chemoattractant gradient. Such gradients may be produced by stromal cells in the local microenvironment, including macrophages and fibroblasts. A better understanding of the mechanisms of cell motility and cytoskeletal regulation may provide novel therapeutic strategies that would block metastatic progression, reducing dissemination of tumor cells and increasing patient survival.

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