iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://pubmed.ncbi.nlm.nih.gov/16501570/
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Mar;12(3):304-6.
doi: 10.1038/nm1375. Epub 2006 Feb 26.

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

Kenneth Cardona  1 , Gregory S Korbutt, Zvonimir Milas, James Lyon, Jose Cano, Wanhong Jiang, Hameeda Bello-Laborn, Brad Hacquoil, Elizabeth Strobert, Shivaprakash Gangappa, Collin J Weber, Thomas C Pearson, Ray V Rajotte, Christian P Larsen
Affiliations

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

Kenneth Cardona et al. Nat Med. 2006 Mar.

Abstract

We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources