Clinical Trial
doi: 10.1212/01.wnl.0000172861.36430.95.
rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease
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- PMID: 16116131
- DOI: 10.1212/01.wnl.0000172861.36430.95
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Clinical Trial
rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease
Neurology.
.
Abstract
The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.
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