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Link to original content: https://pubmed.ncbi.nlm.nih.gov/15896809
Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss - PubMed Skip to main page content
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Review
. 2005 Jun 15;233(1-2):183-98.
doi: 10.1016/j.jns.2005.03.015.

Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss

Axel Petzold  1
Affiliations
Free article
Review

Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss

Axel Petzold. J Neurol Sci. .
Free article

Abstract

This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

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