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Link to original content: https://pubmed.ncbi.nlm.nih.gov/15581674
Opioid-mediated pain sensitivity in mice bred for high voluntary wheel running - PubMed Skip to main page content
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Comparative Study
. 2004 Dec 15;83(3):515-24.
doi: 10.1016/j.physbeh.2004.09.003.

Opioid-mediated pain sensitivity in mice bred for high voluntary wheel running

Guo Li  1 , Justin S Rhodes, Isabelle Girard, Stephen C Gammie, Theodore Garland Jr
Affiliations
Comparative Study

Opioid-mediated pain sensitivity in mice bred for high voluntary wheel running

Guo Li et al. Physiol Behav. .

Abstract

We tested the hypothesis that thermal tail-flick latency, a common measure of pain sensitivity in rodents, would be altered in lines of mice that had been selectively bred for high voluntary wheel-running behavior. Specifically, we predicted that the selected (High-Runner) lines would show decreased pain sensitivity relative to their control (C; randombred) lines, and would respond differently to drugs that block opioid receptors. We first compared tail-flick latency between High-Runner and C female mice during the day (no wheel access) and at night (with wheel access). Second, we compared effects of the opioid antagonist naloxone (10 mg/kg, i.p.) on tail-flick latency during the day (no wheel access). Third, we compared effects of naloxone (5 and 10 mg/kg, i.p.) and naltrexone, a longer-lasting opioid antagonist (0.1, 1, 5, 10, 50, and 100 mg/kg, i.p.), on voluntary wheel running. Tail-flick latencies were longer at night (when mice were active on wheels), but mice from High-Runner and C lines did not differ during the day or night. Administration of naloxone (10 mg/kg, i.p.) decreased tail-flick latency measured during the day, equally in High-Runner and C mice. Naloxone (5 and 10 mg/kg, i.p.) and high doses of naltrexone (50 and 100 mg/kg, i.p.) decreased wheel running equally in High-Runner and C mice. Further studies will be required to determine whether other types of pain sensitivity have also failed to evolve in association with increased voluntary wheel running.

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